Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107981
Abstract: The HIV fusion peptide (FP) is a promising vaccine target. FP-directed monoclonal antibodies from vaccinated macaques have been identified that neutralize up to ∼60% of HIV strains; these vaccinations, however, have involved ∼1 year with… read more here.
Keywords: immune monitoring; fusion peptide; imprint cross; neutralizing responses ... See more keywords
Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biotechnology"
DOI: 10.1038/nbt.3964
Abstract: Studies of the dynamics of the antibody-mediated immune response have been hampered by the absence of quantitative, high-throughput systems to analyze individual antibody-secreting cells. Here we describe a simple microfluidic system, DropMap, in which single… read more here.
Keywords: single cell; secreting cells; igg; immune monitoring ... See more keywords
CMV immune monitoring—Where do we go from here?
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15875
Abstract: It has been more than a decade since the first observational study on the clinical use of cytomegalovirus (CMV) cell-mediated immunity (CMI) was published in AJT. Since then, the promise of CMI has been consistent… read more here.
Keywords: immune monitoring; cmi; cmv; cmv immune ... See more keywords
Epitope competition and neutralizing antidrug antibodies: immune monitoring of antiprogrammed death‐1 therapies and lessons learned from natalizumab
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Dermatology"
DOI: 10.1111/bjd.19137
Abstract: We read with interest the BJD online publication by Gambichler and colleagues1 about a decline of programmed death (PD)-1+ circulating T regulatory cells (Tregs) predicting clinical outcome in anti-PD-1 therapy. The study highlights the potential… read more here.
Keywords: death; immune monitoring; neutralizing antidrug; competition neutralizing ... See more keywords
Functional immune monitoring in severely injured patients—A pilot study
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12837
Abstract: After severe trauma, the resulting excessive inflammatory response is countered by compensatory anti‐inflammatory mechanisms. The systemic inflammatory response to trauma enhanced by inappropriately timed surgical second hits may be detrimental for the patient. On the… read more here.
Keywords: anti inflammatory; injured patients; immune monitoring; severely injured ... See more keywords
Refinement of humoral immune monitoring in kidney transplantation: the role of “hidden” alloreactive memory B cells
Sign Up to like & getrecommendations! Published in 2017 at "Transplant International"
DOI: 10.1111/tri.13014
Abstract: The advent of novel sensitive assays assessing circulating anti‐human leukocyte antigen (HLA) antibodies has allowed recognizing humoral alloimmunity as the main immune‐mediated mechanism responsible for allograft rejection and graft loss in kidney transplantation. However, current… read more here.
Keywords: immune monitoring; kidney transplantation; transplantation; role ... See more keywords
Immune monitoring after pediatric liver transplantation – the prospective ChilSFree cohort study
Sign Up to like & getrecommendations! Published in 2018 at "BMC Gastroenterology"
DOI: 10.1186/s12876-018-0795-x
Abstract: BackgroundAlthough trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessment of functional degree of immunosuppression or… read more here.
Keywords: immune monitoring; study; cohort; liver transplantation ... See more keywords
Immune Monitoring After Allogeneic Hematopoietic Cell Transplantation: Toward Practical Guidelines and Standardization
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2020.00454
Abstract: Hematopoietic cell transplantation (HCT) is often a last resort, but potentially curative treatment option for children suffering from hematological malignancies and a variety of non-malignant disorders, such as bone marrow failure, inborn metabolic disease or… read more here.
Keywords: immune monitoring; cell transplantation; hematopoietic cell; hct ... See more keywords