Engineering DNA Nanostructures to Manipulate Immune Receptor Signaling and Immune Cell Fates.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101844
Abstract: Immune cells sense, communicate, and logically integrate a multitude of environmental signals to make important cell-fate decisions and fulfill their effector functions. These processes are initiated and regulated by a diverse array of immune receptors… read more here.
Keywords: engineering; dna; dna nanostructures; receptor signaling ... See more keywords
Molecular Modeling of the Interaction Between Stem Cell Peptide and Immune Receptor in Plants.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0183-9_8
Abstract: Molecular docking enables comprehensive exploration of interactions between chemical moieties and proteins. Modeling and docking approaches are useful to determine the three-dimensional (3D) structure of experimentally uncrystallized proteins and subsequently their interactions with various inhibitors… read more here.
Keywords: stem cell; molecular modeling; immune receptor; cell peptide ... See more keywords
Adaptation to Host-Specific Bacterial Pathogens Drives Rapid Evolution of a Human Innate Immune Receptor
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.01.058
Abstract: The selective pressure by infectious agents is a major driving force in the evolution of humans and other mammals. Members of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family serve as receptors for bacterial pathogens of… read more here.
Keywords: evolution; ceacam3; bacterial pathogens; receptor ... See more keywords
A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01012
Abstract: Although spatial and temporal elements of immune activation mediate the intensity of the immune response, few tools exist to directly examine these effects. To elucidate the spatiotemporal aspects of innate immune responses, we designed an… read more here.
Keywords: receptor optogenetic; photoactivatable innate; optogenetic inflammation; receptor ... See more keywords
Quantitative Control of Gene-Engineered T cell Activity Through Covalent Attachment of Targeting Ligands to a Universal Immune Receptor.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b11622
Abstract: Universal immune receptors represent a rapidly emerging form of adoptive T cell therapy with the potential to overcome safety and antigen escape challenges faced by conventional chimeric antigen receptor (CAR) T cell therapy. By decoupling… read more here.
Keywords: targeting ligands; universal immune; antigen; receptor ... See more keywords
Differential requirement of TIR enzymatic activities in TIR-type immune receptor SNC1-mediated immunity
Sign Up to like & getrecommendations! Published in 2022 at "Plant Physiology"
DOI: 10.1093/plphys/kiac452
Abstract: Arabidopsis thaliana TIR-type immune receptor SNC1 (Suppressor of npr1-1, constitutive 1) requires NADase, but not the 2′,3′-cAMP/cGMP synthetase activity to trigger in planta immune responses. read more here.
Keywords: receptor snc1; type immune; immune receptor; immune ... See more keywords
Exploiting adaptive immune receptor recombination read recoveries from exome files to identify subsets of ALL and to establish TCR features that correlate with better outcomes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13862
Abstract: The recovery of adaptive immune receptor (IR) recombination reads from tumour‐derived genomics files has advanced the understanding of the immune system's interaction with cancer. This approach has been largely limited to solid tumours, where genomics… read more here.
Keywords: exploiting adaptive; recombination; immune receptor; adaptive immune ... See more keywords
TRUST4 Interrogates the Immune Receptor Repertoire in Oncology and Immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0403
Abstract: The immune receptor repertoire is a set of cellular receptors responsible for recognizing foreign antigens. Characterizing the immune receptor repertoire is critical to understanding mechanisms of human adaptive immunity and developing new approaches to cancer… read more here.
Keywords: oncology; trust4 interrogates; immune receptor; receptor ... See more keywords
Protein-protein interactions in the RPS4/RRS1 immune receptor complex
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006376
Abstract: Plant NLR (Nucleotide-binding domain and Leucine-rich Repeat) immune receptor proteins are encoded by Resistance (R) genes and confer specific resistance to pathogen races that carry the corresponding recognized effectors. Some NLR proteins function in pairs,… read more here.
Keywords: protein; rps4 rrs1; rrs1; receptor ... See more keywords
Plant immune receptor pathways as a united front against pathogens
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011106
Abstract: Plants evolved the innate immune system to activate disease resistance mechanisms and fend off microbial invaders. This system comprises two major signaling cascades initiated by two classes of immune receptors, the cell-surface immune receptors, also… read more here.
Keywords: pathogens plant; plant immune; pathways united; receptor pathways ... See more keywords
Adaptive immune receptor genotyping using the corecount program
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1125884
Abstract: We present a new Rep-Seq analysis tool called corecount, for analyzing genotypic variation in immunoglobulin (IG) and T cell receptor (TCR) genes. corecount is highly efficient at identifying V alleles, including those that are infrequently… read more here.
Keywords: receptor genotyping; analysis; immune receptor; adaptive immune ... See more keywords