Dysregulation of memory B cells and circulating T follicular helper cells is a predictor of poor immune recovery in HIVâinfected patients on antiretroviral therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28559
Abstract: T follicular helper (Tfh) cells and their interactions with B cells within the germinal center play extensive roles in human immunodeficiency virus (HIV) pathology. However, their association with immune reconstitution during antiretroviral therapy (ART) is… read more here.
Keywords: cell; hiv; memory cells; immune recovery ... See more keywords
Machine learning revealed a novel ferroptosis-based classification for diagnosis in antiretroviral therapy-treated HIV patients with defective immune recovery.
Sign Up to like & getrecommendations! Published in 2023 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2022.0138
Abstract: Despite virological suppression, some HIV-infected patients can not restore their CD4+ T lymphocytes after anti-retroviral therapy (ART). These individuals are known as immune non-responders (INRs). INRs are at high risk of developing AIDS and non-AIDS-related… read more here.
Keywords: defective immune; inr; diagnosis; therapy ... See more keywords
Enteropathy and gut dysbiosis as obstacles to achieve immune recovery in undetectable people with HIV: a clinical view of evidence, successes, and projections.
Sign Up to like & getrecommendations! Published in 2023 at "AIDS"
DOI: 10.1097/qad.0000000000003450
Abstract: Immune performance following antiretroviral therapy initiation varies among patients. Despite achieving viral undetectability, a subgroup of patients fails to restore CD4+ T-cell counts during follow-up, which exposes them to non-AIDS defining comorbidities and increased mortality.… read more here.
Keywords: enteropathy gut; achieve immune; gut dysbiosis; dysbiosis obstacles ... See more keywords
Absolute CD4+ T cell count overstate immune recovery assessed by CD4+/CD8+ ratio in HIV-infected patients on treatment
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0205777
Abstract: Objectives To analyse the correlation and concordance between aCD4, CD4%, CD4/CD8, their intra-patient variability, and to compare the immune recovery (IR) rates based on the three parameters in HIV-infected patients after starting antiretroviral therapy. Methods… read more here.
Keywords: cd4 cd8; cd4 cd4; immune recovery; acd4 cd4 ... See more keywords
Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1152951
Abstract: Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore immune function in most people living with human immunodeficiency virus (HIV). However, an important proportion of patients fail to achieve a satisfactory increase… read more here.
Keywords: hiv; insights incomplete; molecular insights; incomplete immune ... See more keywords