The Neuro-Immune-Regulators (NIREGs) Promote Tissue Resilience; a Vital Component of the Host’s Defense Strategy against Neuroinflammation
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroimmune Pharmacology"
DOI: 10.1007/s11481-018-9793-6
Abstract: An effective protective inflammatory response in the brain is crucial for the clearance of pathogens (e.g. microbes, amyloid fibrils, prionSC) and should be closely regulated. However, the CNS seems to have limited tissue resilience to… read more here.
Keywords: regulators niregs; tissue; immune regulators; tissue resilience ... See more keywords
Evolution of negative immune regulators
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DOI: 10.1371/journal.ppat.1007913
Abstract: Hosts must recognize pathogen invasion and respond rapidly. The need for speed requires a low threshold for triggering a response, causing occasional false alarms. Host immune systems therefore require strong negative regulators to shut down… read more here.
Keywords: negative regulators; immune regulators; negative immune; evolution negative ... See more keywords
Microglia: Immune Regulators of Neurodevelopment
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02576
Abstract: Microglia, the tissue-resident macrophages of the central nervous system (CNS), have characterized roles in combating infection, clearing cellular debris, and maintaining tissue homeostasis. In addition to these typical immunological roles, microglia have been revealed to… read more here.
Keywords: microbiome; regulators neurodevelopment; immune regulators; microglia immune ... See more keywords