Association of Anti-Programmed Cell Death 1 Antibody Treatment With Risk of Recurrence of Toxic Effects After Immune-Related Adverse Events of Ipilimumab in Patients With Metastatic Melanoma.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2020.2149
Abstract: Importance Since 2011, many patients with metastatic melanoma have been treated with ipilimumab therapy and have developed severe immune-related adverse events (AEs). Because several immune therapies are now available to treat metastatic melanoma, a better… read more here.
Keywords: therapy; related aes; immune related; metastatic melanoma ... See more keywords
Analysis of Human Leukocyte Antigen DR Alleles, Immune-Related Adverse Events, and Survival Associated With Immune Checkpoint Inhibitor Use Among Patients With Advanced Malignant Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.46400
Abstract: Key Points Question What is the association between immune-related adverse events (irAEs) and survival after immune checkpoint inhibitor (ICI) therapy initiation and human leukocyte antigen genes in patients with advanced malignant melanoma? Findings In this… read more here.
Keywords: advanced malignant; patients advanced; immune related; related adverse ... See more keywords
Chronic Immune-Related Adverse Events Following Adjuvant Anti-PD-1 Therapy for High-risk Resected Melanoma.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2021.0051
Abstract: Importance Agents targeting programmed cell death 1 (PD-1)/PD ligand 1 (PD-L1) improve long-term survival across many advanced cancers and are now used as adjuvant therapy for resected stage III and IV melanomas. The incidence and… read more here.
Keywords: chronic immune; anti therapy; immune related; therapy ... See more keywords
Association of Immune-Related Adverse Events With Efficacy of Atezolizumab in Patients With Non–Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2023 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2022.7711
Abstract: This analysis of pooled data from 3 randomized clinical trials evaluates the association between immune-related adverse events and atezolizumab efficacy in patients with advanced non–small cell lung cancer. read more here.
Keywords: association immune; non small; immune related; small cell ... See more keywords
Immune‐related gene TM4SF18 could promote the metastasis of gastric cancer cells and predict the prognosis of gastric cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13321
Abstract: Gastric cancer (GC) is one of the most common malignancies in the world, and the search for better markers has become one of the challenges today. It has been found that the L6 superfamily regulates… read more here.
Keywords: prognosis; immune related; tm4sf18; gastric cancer ... See more keywords
IL‐7 germline variant: setting the stage for immune‐related adverse events
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DOI: 10.1002/1878-0261.13392
Abstract: Treatment with immune checkpoint inhibitors (ICIs) is frequently associated with immune‐related adverse events (irAEs). A new study identified an interleukin 7 (IL‐7) allelic variant—rs16906115—as a major risk factor for the development of ICI‐associated irAEs. This… read more here.
Keywords: variant setting; germline variant; immune related; related adverse ... See more keywords
Immune signaling pathways in the endoparasitoid, Pteromalus puparum.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21629
Abstract: Parasitoids serve as effective biocontrol agents for agricultural pests. However, they face constant challenges from host immune defense and numerous pathogens and must develop potent immune defense against these threats. Despite the recent advances in… read more here.
Keywords: immune; immune related; pteromalus puparum; endoparasitoid pteromalus ... See more keywords
Identification of a novel 10 immune‐related genes signature as a prognostic biomarker panel for gastric cancer
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DOI: 10.1002/cam4.4180
Abstract: Emerging evidence indicates that immune infiltrating cells in tumor microenvironment (TME) correlates with the development and progression of gastric cancer (GC). This study aimed to systematically investigate the immune‐related genes (IRGs) to develop a prognostic… read more here.
Keywords: novel immune; gastric cancer; immune related; identification novel ... See more keywords
Identification of novel subtypes based on ssGSEA in immune-related prognostic signature for tongue squamous cell carcinoma.
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DOI: 10.1002/cam4.4341
Abstract: BACKGROUND Tongue squamous cell carcinoma (TSCC) is characterized by aggressive invasion and poor prognosis. Currently, immune checkpoint inhibitors may prolong overall survival compared with conventional treatments. However, PD1/PDL1 remain inapplicable in predicting the prognosis of TSCC;… read more here.
Keywords: tongue squamous; ssgsea; immune related; squamous cell ... See more keywords
Pre-treatment comorbidities, C-reactive protein and eosinophil count, and immune-related adverse events as predictors of survival with checkpoint inhibition for multiple tumour entities.
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DOI: 10.1002/cam4.5919
Abstract: BACKGROUND The development of immune-related adverse events (irAEs) may be associated with clinical efficacy of checkpoint inhibitors (CPIs) in patients with cancer. We therefore investigated the effect of irAEs and pre-treatment parameters on outcome in… read more here.
Keywords: eosinophil count; immune related; tumour entities; pre treatment ... See more keywords
A Novel Clinical Immune-Related Prognostic Model Predicts the Overall Survival of Mantle Cell Lymphoma.
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DOI: 10.1002/hon.2994
Abstract: BACKGROUND The mantle cell lymphoma (MCL) International Prognostic Index (MIPI) and combined MIPI (MIPI-c) are commonly used for risk classification of MCL patients. However, these indexes lack immune-related parameters. The purpose of this study was… read more here.
Keywords: clinical immune; mantle cell; risk; cell ... See more keywords