Abalign: a comprehensive multiple sequence alignment platform for B-cell receptor immune repertoires.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad400
Abstract: The utilization of high-throughput sequencing (HTS) for B-cell receptor (BCR) immune repertoire analysis has become widespread in the fields of adaptive immunity and antibody drug development. However, the sheer volume of sequences generated by these… read more here.
Keywords: sequence alignment; immune repertoires; multiple sequence; alignment ... See more keywords
Positive selection of immune repertoires: A short further history
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13144
Abstract: The importance of the negative selection of self‐reacting cells from immune repertoires was easily recognized since it would militate against autoimmune disease. However, while the existence of positive selection in the auditioning of newly formed… read more here.
Keywords: negative selection; selection immune; positive selection; immune repertoires ... See more keywords
Investigation of immune repertoires in thymoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.e21117
Abstract: e21117Background: Paraneoplastic autoimmune manifestations are seen in 30 to 40% of thymoma cases. Thymus plays the main role in T- cell maturation with ‘negative selection’ of autoreactive T-cells... read more here.
Keywords: investigation immune; repertoires thymoma; immune repertoires; oncology ... See more keywords
T Cell Receptor Immune Repertoires Are Promptly Reconstituted After Methicillin-Resistant Staphylococcus aureus Infection
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.02012
Abstract: T cells represent a subset of lymphocytes characterized by immunosurveillance and immunoregulation function. Peripheral blood mononuclear cells (PBMCs) are enriched in T cells, which exert critical antimicrobial roles in infectious diseases. High-throughput sequencing of the… read more here.
Keywords: mrsa infection; infection; resistant staphylococcus; cell receptor ... See more keywords
Measuring Intratumoral Heterogeneity of Immune Repertoires
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00512
Abstract: There is considerable clinical and fundamental value in measuring the clonal heterogeneity of T and B cell expansions in tumors and tumor-associated lymphoid structures—along with the associated heterogeneity of the tumor neoantigen landscape—but such analyses… read more here.
Keywords: heterogeneity; intratumoral heterogeneity; model; immune repertoires ... See more keywords
High-throughput Treg cell receptor sequencing reveals differential immune repertoires in rheumatoid arthritis with kidney deficiency
Sign Up to like & getrecommendations! Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.14837
Abstract: Background Regulatory T (Treg) cells are important immune cells that are regulated by adaptive immunity in the composition of Treg-cell subsets and T-cell receptors (TCRs). Treg cells are related to most autoimmune diseases, such as… read more here.
Keywords: treg; treg cell; immune repertoires; treg cells ... See more keywords