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   Articles with "immune reprogramming" as a keyword



High versus low dose irradiation for tumor immune reprogramming.

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recommendations! Published in 2020 at "Current opinion in biotechnology"

DOI: 10.1016/j.copbio.2020.08.001

Abstract: Local administration of ionizing radiation to tumors can promote anticancer immune responses that lead to the abscopal regression of distant metastases, especially in patients receiving systemic immune-checkpoint inhibitors. Growing preclinical evidence indicates that high-dose irradiation… read more here.

Keywords: irradiation; low dose; immune reprogramming; tumor immune ... See more keywords
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Dedifferentiation of Epithelial Cells Incorporates Immune Reprogramming.

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recommendations! Published in 2021 at "Trends in cell biology"

DOI: 10.1016/j.tcb.2021.01.007

Abstract: Recent innovations in immunotherapies have cured cancers but remain ineffective in pancreatic cancer, which exhibits intertwined dynamics of dedifferentiation of epithelium and reprogramming ofimmunosuppression. Emerging evidence reveals the biological mechanisms through which dedifferentiation recapitulates immune… read more here.

Keywords: epithelial cells; immune reprogramming; cells incorporates; incorporates immune ... See more keywords

Tumor-Homing and Immune-Reprogramming Cellular Nanovesicles for Photoacoustic Imaging-Guided Phototriggered Precise Chemoimmunotherapy.

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recommendations! Published in 2022 at "ACS nano"

DOI: 10.1021/acsnano.2c04983

Abstract: Many studies have focused on developing effective therapeutic strategies to selectively destroy primary tumors, eliminate metastatic lesions, and prevent tumor recurrence with minimal side effects on normal tissues. In this work, we synthesized engineered cellular… read more here.

Keywords: tumor homing; homing immune; cellular nanovesicles; immune reprogramming ... See more keywords

Immune reprogramming of tumor microenvironments by cytotoxic antibody-drug conjugate payloads.

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recommendations! Published in 2025 at "Molecular cancer therapeutics"

DOI: 10.1158/1535-7163.mct-25-0682

Abstract: Antibody-drug conjugates (ADCs) have recently emerged as an effective treatment option for cancer. While the fundamental mechanisms of direct tumor cell killing by various ADC payloads have been established, their impact on the tumor microenvironment… read more here.

Keywords: immune reprogramming; reprogramming tumor; tumor; antibody drug ... See more keywords

Overcoming Immune Therapy Resistance in Cancer Through Innate Immune Reprogramming

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recommendations! Published in 2025 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms26199554

Abstract: Overcoming immune resistance remains the critical barrier to durable immunotherapy responses. Tumors with non-inflamed, “cold” microenvironments exclude cytotoxic lymphocytes and evade checkpoint blockade. Innate nucleic acid-sensing pathways—including TLRs, RIG-I-like RNA sensors, and the cGAS–STING DNA-sensing… read more here.

Keywords: immune reprogramming; immune therapy; overcoming immune; therapy resistance ... See more keywords