Emerging JWA-targeted Pt(IV) prodrugs conjugated with CX-4945 to overcome chemo-immune-resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.10.184
Abstract: Two Pt(IV) prodrugs, Cx-platin-Cl and Cx-DN604-Cl, derived from the conjugation of cisplatin or DN604 with a CK2 inhibitor CX-4945, were constructed to suppress DNA damage repair-related elements. During in vitro biological studies, the Pt(IV) prodrugs had… read more here.
Keywords: platin dn604; immune resistance; chemo immune; resistance ... See more keywords
Tyramine's modulation of immune resistance functions in Litopenaeus vannamei and its signal pathway
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2019.01.008
Abstract: ABSTRACT Tyramine (TA), a neuroactive chemical, plays various important physiological roles in insects by activating distinct G‐protein‐coupled receptors (GPCRs). In this study, we investigated the effects of by pharmacological injection of TA on immune resistance… read more here.
Keywords: immune resistance; tyramine; injection; shrimp ... See more keywords
circ_0004140 promotes LUAD tumor progression and immune resistance through circ_0004140/miR-1184/CCL22 axis
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00983-w
Abstract: Lung adenocarcinoma (LUAD) is a highly prevalent cancer with high mortality. Immune resistance and tumor metastasis are the pivotal factors for the promotion of LUAD. CircRNAs have been revealed a crucial pre-clinical diagnostic and therapeutic… read more here.
Keywords: circ 0004140; immune resistance; resistance; mir 1184 ... See more keywords
Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09370-z
Abstract: Lung adenocarcinoma (LUAD)-derived Wnts increase cancer cell proliferative/stemness potential, but whether they impact the immune microenvironment is unknown. Here we show that LUAD cells use paracrine Wnt1 signaling to induce immune resistance. In TCGA, Wnt1… read more here.
Keywords: lung adenocarcinoma; dendritic cells; immune resistance; wnt1 ... See more keywords
Cancer cells under immune attack acquire CD47-mediated adaptive immune resistance independent of the myeloid CD47-SIRPα axis
Sign Up to like & getrecommendations! Published in 2021 at "Oncoimmunology"
DOI: 10.1080/2162402x.2021.2005344
Abstract: ABSTRACT Cancer cells exploit CD47 overexpression to inhibit phagocytic elimination and neoantigen processing via the myeloid CD47-SIRPα axis and thereby indirectly evade adaptive T cell immunity. Here, we report on a hitherto unrecognized direct immunoinhibitory… read more here.
Keywords: cancer cells; immune resistance; cancer; cd47 ... See more keywords
CDK1/2/5 inhibition overcomes IFNG-mediated adaptive immune resistance in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2020 at "Gut"
DOI: 10.1136/gutjnl-2019-320441
Abstract: Objective Adaptive immune resistance mediated by the cytokine interferon gamma (IFNG) still constitutes a major problem in cancer immunotherapy. We develop strategies for overcoming IFNG-mediated adaptive immune resistance in pancreatic ductal adenocarcinoma cancer (PDAC). Design… read more here.
Keywords: cdk1; adaptive immune; immune resistance; cancer ... See more keywords
Abstract 6409: Non-redundant mechanisms of immune resistance to radiotherapy converge on innate immunity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6409
Abstract: Multiple studies have demonstrated synergy between immune checkpoint blockade (ICB) and radiotherapy (RT) in preclinical murine models; however, randomized trials of RT/ICB have been inconsistent in patients with solid tumors. To better understand this discordance,… read more here.
Keywords: icb; non redundant; cd47; resistance ... See more keywords
Abstract 6652: Overcoming immune resistance in DNA mismatch repair deficient tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6652
Abstract: Patients with Lynch Syndrome, an inherited mismatch repair deficiency, have an increased risk for developing microsatellite unstable (MSI-H) cancers. Our team recently identified shared immunogenic frameshift peptides in patient tumors that can be targets of… read more here.
Keywords: immune resistance; resistance; mismatch repair; msi ... See more keywords
CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti–PD-L1 Treatment
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-19-0608
Abstract: Genetic screens identify the kinase CAMK1D as a regulator of antitumor immune resistance in anti–PD-L1–refractory cancer. CAMK1D activation in tumor cells, through CTL stimulation of the Fas receptor, inhibits caspase-mediated cell death of anti–PD-L1–refractory tumors.… read more here.
Keywords: immune resistance; resistance; camk1d; tumor ... See more keywords
Hallmarks of Resistance to Immune-Checkpoint Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-20-0586
Abstract: Abstract Immune-checkpoint inhibitors (ICI), although revolutionary in improving long-term survival outcomes, are mostly effective in patients with immune-responsive tumors. Most patients with cancer either do not respond to ICIs at all or experience disease progression… read more here.
Keywords: hallmarks resistance; checkpoint inhibitors; immune checkpoint; resistance ... See more keywords
IDO1 as a mechanism of adaptive immune resistance to anti-PD1 monotherapy in HNSCC.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.6053
Abstract: 6053Background: Patients with recurrent/metastatic human papillomavirus-associated head and neck squamous cell carcinoma (HPV-HNSCC) demonstrate improved response rates to anti-PD-1 blockade, which... read more here.
Keywords: adaptive immune; immune resistance; ido1 mechanism; resistance anti ... See more keywords