Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149410
Abstract: Activation of the coagulation cascade is a critical, evolutionarily conserved mechanism that maintains hemostasis by rapidly forming blood clots in response to bloodâborne infections and damaged blood vessels. Coagulation is a key component of innate… read more here.
Keywords: signaling immunothrombosis; coagulation; immune signaling; immunothrombosis new ... See more keywords
Sensory Neurons Co-opt Classical Immune Signaling Pathways to Mediate Chronic Itch
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.08.006
Abstract: Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to expel invading pathogens and noxious environmental stimuli. It is well established that these responses are also associated with chronic inflammatory diseases, including asthma and… read more here.
Keywords: signaling pathways; itch; classical immune; immune signaling ... See more keywords
Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.01.012
Abstract: Intracellular pathogens alter their host cells' mechanics to promote dissemination through tissues. Conversely, host cells may respond to the presence of pathogens by altering their mechanics to limit infection. Here, we monitored epithelial cell monolayers… read more here.
Keywords: mechanical competition; immune signaling; innate immune; cell ... See more keywords
The emerging roles of NOD-like receptors in antiviral innate immune signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.12.127
Abstract: Viral infection triggers host pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns or danger-associated molecular patterns to initiate antiviral innate immune responses. NOD-like receptors (NLRs) are a subgroup of cytosolic PRRs. While substantial advances… read more here.
Keywords: innate; signaling pathways; antiviral innate; immune signaling ... See more keywords
K63 ubiquitination in immune signaling
Sign Up to like & getrecommendations! Published in 2022 at "Trends in Immunology"
DOI: 10.1016/j.it.2021.12.005
Abstract: Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent evidence has shown that the control of multiple immune functions, including chronic inflammation, pathogen responses, lymphocyte activation, and regulatory signaling, is altered by… read more here.
Keywords: ubiquitination immune; ubiquitination; immune signaling; immunology ... See more keywords
Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator?
Sign Up to like & getrecommendations! Published in 2019 at "Trends in Neurosciences"
DOI: 10.1016/j.tins.2019.02.005
Abstract: Social interactions are fundamental to survival and overall health. The mechanisms underlying social behavior are complex, but we now know that immune signaling plays a fundamental role in the regulation of social interactions. Prolonged or… read more here.
Keywords: immune signaling; social behavior; neuro immune; immune mechanisms ... See more keywords
Endocrine-immune signaling as a predictor of survival: A prospective study in developing songbird chicks.
Sign Up to like & getrecommendations! Published in 2018 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2018.08.008
Abstract: Immune function varies with an animal's endocrine physiology and energy reserves, as well as its abiotic and biotic environment. This context-dependency is thought to relate to adaptive trade-off resolution that varies from one context to… read more here.
Keywords: mass; physiology; immune signaling; prospective study ... See more keywords
Visualizing the Molecular Dynamics of Adaptive and Innate Immune Signaling at the Cell Surface
Sign Up to like & getrecommendations! Published in 2019 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927619006949
Abstract: One of the great challenges in biology is to understand the emergence of spatial and temporal order in cellular processes. This challenge is particularly relevant to cell signaling, where the localized assembly and activation of… read more here.
Keywords: dynamics adaptive; molecular dynamics; cell; immune ... See more keywords
Understanding immune signaling using advanced imaging techniques
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society Transactions"
DOI: 10.1042/bst20210479
Abstract: Advanced imaging is key for visualizing the spatiotemporal regulation of immune signaling which is a complex process involving multiple players tightly regulated in space and time. Imaging techniques vary in their spatial resolution, spanning from… read more here.
Keywords: signaling using; using advanced; advanced imaging; understanding immune ... See more keywords
Activation loop phosphorylaton of a non-RD receptor kinase initiates plant innate immune signaling
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2108242118
Abstract: Significance Protein kinases lacking Arg in the catalytic loop HxD motif (i.e., non-RD kinases) are associated with innate immune signaling across kingdoms. Phosphorylation activates plant immune receptor kinases (RKs), but the mechanistic details of activation… read more here.
Keywords: plant; kinase; immune signaling; activation ... See more keywords
A PDLP-NHL3 complex integrates plasmodesmal immune signaling cascades
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216397120
Abstract: The plant immune system relies on the perception of molecules that signal the presence of a microbe threat. This triggers signal transduction that mediates a range of cellular responses via a collection of molecular machinery… read more here.
Keywords: plasmodesmal closure; nhl3 complex; signaling cascades; pdlp nhl3 ... See more keywords