Structural basis of NLR activation and innate immune signalling in plants
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DOI: 10.1007/s00251-021-01242-5
Abstract: Animals and plants have NLRs (nucleotide-binding leucine-rich repeat receptors) that recognize the presence of pathogens and initiate innate immune responses. In plants, there are three types of NLRs distinguished by their N-terminal domain: the CC… read more here.
Keywords: innate; innate immune; domain nlrs; immune signalling ... See more keywords
Toll-like receptor/interleukin-1 domain innate immune signalling pathway genetic variants are candidate predictors for severe gastrointestinal toxicity risk following 5-fluorouracil-based chemotherapy
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DOI: 10.1007/s00280-018-3729-y
Abstract: PurposeSevere gastrointestinal (GI) toxicity is a common adverse effect following 5-fluorouracil (5-FU)-based chemotherapy treatment. The presence of severe GI toxicity leads to treatment revisions, sub-optimal therapy outcomes, and decreases to patients’ quality of life. There… read more here.
Keywords: risk; immune signalling; toxicity; signalling pathway ... See more keywords
The actin nucleator Spir-1 is a virus restriction factor that promotes innate immune signalling
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DOI: 10.1371/journal.ppat.1010277
Abstract: Cellular proteins often have multiple and diverse functions. This is illustrated with protein Spir-1 that is an actin nucleator, but, as shown here, also functions to enhance innate immune signalling downstream of RNA sensing by… read more here.
Keywords: spir; actin nucleator; factor; immune signalling ... See more keywords