Prognostic attributes of immune signatures in soft tissue sarcomas show differential dependencies on tumor mutational burden
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34333
Abstract: Cellular and intrinsic markers of sarcoma immunogenicity are poorly understood. To gain insight into whether tumor–immune interactions correlate with clinical aggressiveness, the authors examined the prognostic significance of immune gene signatures in combination with tumor… read more here.
Keywords: attributes immune; immune signatures; tumor mutational; prognostic attributes ... See more keywords
Comparisons of the immunological landscape between COVID-19, influenza, and respiratory syncytial virus patients by clustering analysis
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Structural Biotechnology Journal"
DOI: 10.1016/j.csbj.2021.04.043
Abstract: Background COVID-19 has stronger infectivity and ahigherrisk forseverity than mostother contagious respiratory illnesses. Themechanisms underlying this difference remain unclear. Methods We compared the immunological landscape betweenCOVID-19 and two other contagious respiratory illnesses (influenza and respiratory… read more here.
Keywords: immunity; analysis; covid; immune signatures ... See more keywords
Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00477-5
Abstract: Richter syndrome (RS) refers to transformation of chronic lymphocytic leukemia (CLL) to an aggressive lymphoma, most commonly diffuse large B-cell lymphoma. RS is known to be associated with a number of genetic alterations such as… read more here.
Keywords: distinct immune; cll; lymphocytic leukemia; immune signatures ... See more keywords
Mimicking immune signatures of flavivirus infection with targeted adjuvants improves dengue subunit vaccine immunogenicity
Sign Up to like & getrecommendations! Published in 2019 at "NPJ Vaccines"
DOI: 10.1038/s41541-019-0119-3
Abstract: Neutralizing antibodies (nAbs) are a critical component for protection against dengue virus (DENV) infection, but little is known about the immune mechanisms governing their induction and whether such mechanisms can be harnessed for vaccine development.… read more here.
Keywords: infection; tlr agonists; immune signatures; dengue ... See more keywords
B2M overexpression correlates with malignancy and immune signatures in human gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84465-6
Abstract: Because of the limited treatment strategy of gliomas, the key of diagnosis and treatment is finding new molecular biomarkers. Here, we explored the potential of β2-microglobulin (B2M) to serve as a hopeful candidate for immunotherapy… read more here.
Keywords: gliomas; overexpression correlates; b2m; b2m expression ... See more keywords
Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111600119
Abstract: Significance Type I interferons (IFN-I) exhibit various biological effects during viral infections, and they have been successfully used for clinical treatment of viral diseases. Humans express 12 IFNα subtypes, which strongly differ in their antiviral… read more here.
Keywords: immune signatures; ifn; cov infection; sars cov ... See more keywords
Immune signatures, testing, and management of febrile neutropenia in pediatric cancer patients
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2023.2168646
Abstract: ABSTRACT Introduction Infectious complications, particularly invasive bacterial and fungal infections, are still a major cause of morbidity in pediatric cancer patients and are associated with significant mortality. Over the last few years, there has been… read more here.
Keywords: pediatric cancer; immune signatures; cancer patients; testing management ... See more keywords
Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.231837.117
Abstract: Long interspersed nuclear element-1 (LINE-1 or L1) retrotransposons are normally suppressed in somatic tissues mainly due to DNA methylation and antiviral defense. However, the mechanism to suppress L1s may be disrupted in cancers, thus allowing… read more here.
Keywords: retrotransposition gastrointestinal; retrotransposition; expression; immune signatures ... See more keywords
Novel immune signatures associated with dysplastic naevi and primary cutaneous melanoma in human skin
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Dermatology"
DOI: 10.1111/exd.13805
Abstract: Dysplastic naevi (DN) are benign lesions with atypical features intermediate between that of common melanocytic naevi (CMN) and malignant melanoma (MM). Debate remains over whether DN represent progressive lesions from CMN. Through gene expression profiling… read more here.
Keywords: melanoma; novel immune; progressive increases; dysplastic naevi ... See more keywords
Machine learning predicts cancer subtypes and progression from blood immune signatures
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0264631
Abstract: Clinical adoption of immune checkpoint inhibitors in cancer management has highlighted the interconnection between carcinogenesis and the immune system. Immune cells are integral to the tumour microenvironment and can influence the outcome of therapies. Better… read more here.
Keywords: blood immune; immune signatures; tumour; blood ... See more keywords
Unique cellular immune signatures of multisystem inflammatory syndrome in children
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1010915
Abstract: The clinical presentation of MIS-C overlaps with other infectious/non-infectious diseases such as acute COVID-19, Kawasaki disease, acute dengue, enteric fever, and systemic lupus erythematosus. We examined the ex-vivo cellular parameters with the aim of distinguishing… read more here.
Keywords: unique cellular; immune signatures; cellular immune; multisystem inflammatory ... See more keywords