Factors Associated With Successful Discontinuation of Immune Suppression After Allogeneic Hematopoietic Cell Transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2019.2974
Abstract: Importance Immune suppression discontinuation is routinely attempted after allogeneic hematopoietic cell transplantation (HCT) and under current practices may lead to graft-vs-host disease (GVHD)-associated morbidity and death. However, the likelihood and predictive factors associated with successful… read more here.
Keywords: suppression; immune suppression; suppression discontinuation; factors associated ... See more keywords
Ovarian Cancer: Therapeutic Strategies to Overcome Immune Suppression.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-73359-9_3
Abstract: Ovarian cancer generally escapes diagnosis until the advanced stages. High-grade serous ovarian cancer (HGSOC) is the most frequently occurring form of this malaise and is a disease which has the highest mortality rate of gynecologic… read more here.
Keywords: immune suppression; cancer therapeutic; ovarian cancer; biology ... See more keywords
Nonbiologic Immune Suppression in Ulcerative Colitis.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology clinics of North America"
DOI: 10.1016/j.gtc.2020.07.003
Abstract: This article reviews nonbiologic immunosuppressive agents in the induction and maintenance of remission of ulcerative colitis. Based on meta-analyses and North American guidelines, azathioprine, mercaptopurine, and methotrexate monotherapy are not recommended for induction therapy. Thiopurines… read more here.
Keywords: colitis; maintenance; nonbiologic immune; suppression ulcerative ... See more keywords
The homeobox protein VentX reverts immune suppression in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-04567-0
Abstract: Immune suppression in the tumor microenvironment (TME) is a central obstacle to effective immunotherapy. Tumor-associated macrophages (TAMs) are key components of the TME. Although TAMs have been viewed as an ideal target of intervention to… read more here.
Keywords: immune suppression; homeobox protein; suppression tumor; ventx ... See more keywords
Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07505-2
Abstract: Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions. Metabolically, neutrophils are often discounted as purely glycolytic.… read more here.
Keywords: suppression; oxidative neutrophils; immune suppression; tumour elicited ... See more keywords
IMMU-43. POLYAMINE METABOLISM REGULATES MYELOID IMMUNE SUPPRESSION IN GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.535
Abstract: Tumor-associated myeloid cells, which consist of tumor associated macrophages and myeloid-derived suppressor cells (MDSCs), make up a majority of cellular infiltrates in glioma. Glioma infiltrating MDSCs highly express arginase-1 (Arg-1), a catabolic enzyme thought to… read more here.
Keywords: glioma; immune suppression; polyamine; generation ... See more keywords
Antigen copy number and antibody dose can determine the outcome of erythrocyte alloimmunization inducing either antibody‐mediated immune suppression or enhancement in a murine model
Sign Up to like & getrecommendations! Published in 2023 at "Transfusion"
DOI: 10.1111/trf.17284
Abstract: The administration of anti‐D for the prevention of hemolytic disease of the fetus and newborn is one of the most successful clinical uses of the phenomenon of antibody‐mediated immune suppression (AMIS). However, despite adequate prophylaxis,… read more here.
Keywords: immune suppression; antibody mediated; mediated immune; copy number ... See more keywords
PO-318 Intestine-specific homeobox gene ISX integrates IL6 signaling, tryptophan catabolism, and immune suppression
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.831
Abstract: Introduction The intestine-specific homeobox transcription factor intestine specific homeobox (ISX) is an IL6-inducible protooncogene implicated in the development of hepatocellular carcinoma, but its mechanistic contributions to this process are undefined. Material and methods In this… read more here.
Keywords: hepatocellular carcinoma; intestine specific; immune suppression; tryptophan ... See more keywords
PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression
Sign Up to like & getrecommendations! Published in 2023 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2023/2994316
Abstract: Glioblastoma is characterized as one of the deadliest cancers in humans. The survival time is not improved by standard treatment. Although immunotherapy has revolutionized cancer treatment, the current therapy targets for glioblastoma patients are not… read more here.
Keywords: ptpn18 serves; glioblastoma; immune suppression; ptpn18 ... See more keywords
Upregulation of PD-L1 via HMGB1-Activated IRF3 and NF-κB Contributes to UV Radiation-Induced Immune Suppression.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-3134
Abstract: Solar ultraviolet radiation (UVR) suppresses skin immunity, which facilitates initiation of skin lesions and establishment of tumors by promoting immune evasion. It is unclear whether immune checkpoints are involved in the modulation of skin immunity… read more here.
Keywords: radiation; hmgb1; induced immune; upregulation via ... See more keywords
Polyunsaturated Fatty Acid–Bound α-Fetoprotein Promotes Immune Suppression by Altering Human Dendritic Cell Metabolism
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/0008-5472.can-22-3551
Abstract: α-Fetoprotein (AFP) is a secreted tumor protein and biomarker with impact on immunity. Fatty acid–bound AFP promotes immune suppression by skewing human dendritic cell metabolism toward glycolysis and reduced immune stimulation. read more here.
Keywords: immune suppression; human dendritic; promotes immune; acid bound ... See more keywords