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1
Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4hi0921-514rr
Abstract: Transitory appearance of immune suppressive polymorphonuclear neutrophils (PMNs) defined as myeloid‐derived suppressor cells (PMNs‐MDSCs) in newborns is important for their protection from inflammation associated with newly established gut microbiota. Here, we report that inhibition of…
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Keywords:
mdscs newborns;
pmns mdscs;
suppressive activity;
immune suppressive ... See more keywords
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2
Published in 2023 at "Small"
DOI: 10.1002/smll.202207668
Abstract: Although photodynamic immunotherapy has been promoted in the clinical practice of cholangiocarcinoma, the insensitivity to photodynamic immunotherapy remains to be a great problem. This can be largely attributed to an immune-suppressive tumor microenvironment (TME) manifested…
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Keywords:
three one;
immunotherapy;
cholangiocarcinoma;
photodynamic immunotherapy ... See more keywords
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1
Published in 2022 at "Liver International"
DOI: 10.1111/liv.15383
Abstract: Dickkopf‐1 (DKK1) is associated with poor prognosis in intrahepatic cholangiocarcinoma (iCCA), but the mechanisms behind this are unclear. Here, we show that DKK1 plays an immune regulatory role in vivo and inhibition reduces tumour growth.
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Keywords:
intrahepatic cholangiocarcinoma;
dkk1 drives;
immune suppressive;
drives immune ... See more keywords
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1
Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abm6420
Abstract: The accumulation of immune-suppressive myeloid cells is a critical determinant of resistance to anti–programmed death-1 (PD-1) therapy in advanced clear cell renal cell carcinoma (ccRCC). In preclinical models, the tyrosine kinase inhibitor sitravatinib enhanced responses…
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Keywords:
cell;
suppressive myeloid;
myeloid cells;
immune suppressive ... See more keywords
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1
Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-pl03-03
Abstract: Advances in basic, translational and clinical research have revealed the power of cancer immune therapy. Checkpoint inhibitors and adoptive T cell therapies are novel, FDA approved therapeutic strategies that promote recruitment to and activation of…
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Keywords:
therapy;
immune suppressive;
immune therapy;
cancer ... See more keywords
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2
Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2324
Abstract: Background: Treatment response to chemoradiotherapy and immune checkpoint blockade is limited in gastroesophageal adenocarcinoma (GEA). This is likely caused by the fact that the majority of GEAs, belonging to the chromosomally instable subgroup (70%), are…
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Keywords:
suppressive factors;
tumor biopsies;
secretome freshly;
immune suppressive ... See more keywords
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Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-0400
Abstract: Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells (GSCs). Pan-cancer analyses have revealed that stemness of cancer cells correlates positively with immunosuppressive pathways in many solid tumors, including GBM,…
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Keywords:
immune suppressive;
clock;
suppressive microglia;
tumor ... See more keywords
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Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-20-0074
Abstract: Tenascin-C, an extracellular matrix protein, contributes to immune suppression in head and neck tumors. Tenascin-C orchestrates immune-suppressive niches by directing spatial distribution of Tregs and myeloid cells, leading to invasive disease. Inherent immune suppression represents…
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Keywords:
tenascin;
immune suppressive;
orchestrates immune;
oral squamous ... See more keywords
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1
Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-21-0457
Abstract: An IDO-specific peptide vaccine is demonstrated to target IDO+ cells, enhancing vaccine-induced immune responses against non-IDO tumor antigens. These effects reduce tumor growth and inhibit immune-suppressive myeloid populations in multiple tumor models.
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Keywords:
suppressive myeloid;
tumor;
myeloid populations;
ido ... See more keywords
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1
Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-a72
Abstract: Polymorphnuclear myeloid-derived suppressor cells (PMN-MDSCs) are a subset of MDSCs that are expanded and accumulated in several cancers. The main role of PMN-MDSCs in cancer is the suppression of antitumor immune responses, which leads to…
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Keywords:
immune suppressive;
pmn mdscs;
suppressive activity;
cancer ... See more keywords
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Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.1799.1799
Abstract: Background: MultipleMyeloma (MM) is a malignant plasma cell disorder, accounting for approximately 10% of all haematological malignancies. The intrinsic ability of the malignant cells to evade the host immune system is one of the key…
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Keywords:
siglec;
immune suppressive;
surface;
expression ... See more keywords