Mechanisms regulating transitory suppressive activity of neutrophils in newborns: PMNs‐MDSCs in newborns
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4hi0921-514rr
Abstract: Transitory appearance of immune suppressive polymorphonuclear neutrophils (PMNs) defined as myeloid‐derived suppressor cells (PMNs‐MDSCs) in newborns is important for their protection from inflammation associated with newly established gut microbiota. Here, we report that inhibition of… read more here.
Keywords: mdscs newborns; pmns mdscs; suppressive activity; immune suppressive ... See more keywords
Three-in-One Oncolytic Adenovirus System Initiates a Synergetic Photodynamic Immunotherapy in Immune-Suppressive Cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202207668
Abstract: Although photodynamic immunotherapy has been promoted in the clinical practice of cholangiocarcinoma, the insensitivity to photodynamic immunotherapy remains to be a great problem. This can be largely attributed to an immune-suppressive tumor microenvironment (TME) manifested… read more here.
Keywords: three one; immunotherapy; cholangiocarcinoma; photodynamic immunotherapy ... See more keywords
DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti‐DKK1 therapeutic DKN‐01
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15383
Abstract: Dickkopf‐1 (DKK1) is associated with poor prognosis in intrahepatic cholangiocarcinoma (iCCA), but the mechanisms behind this are unclear. Here, we show that DKK1 plays an immune regulatory role in vivo and inhibition reduces tumour growth. read more here.
Keywords: intrahepatic cholangiocarcinoma; dkk1 drives; immune suppressive; drives immune ... See more keywords
A phase 1-2 trial of sitravatinib and nivolumab in clear cell renal cell carcinoma following progression on antiangiogenic therapy
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abm6420
Abstract: The accumulation of immune-suppressive myeloid cells is a critical determinant of resistance to anti–programmed death-1 (PD-1) therapy in advanced clear cell renal cell carcinoma (ccRCC). In preclinical models, the tyrosine kinase inhibitor sitravatinib enhanced responses… read more here.
Keywords: cell; suppressive myeloid; myeloid cells; immune suppressive ... See more keywords
Abstract PL03-03: Taming the beast: Strategies to target the immune-suppressive macrophage to enhance cancer immune therapy
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-pl03-03
Abstract: Advances in basic, translational and clinical research have revealed the power of cancer immune therapy. Checkpoint inhibitors and adoptive T cell therapies are novel, FDA approved therapeutic strategies that promote recruitment to and activation of… read more here.
Keywords: therapy; immune suppressive; immune therapy; cancer ... See more keywords
Abstract 2324: Characterizing the secretome of freshly dissociated gastroesophageal tumor biopsies to identify immune suppressive factors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2324
Abstract: Background: Treatment response to chemoradiotherapy and immune checkpoint blockade is limited in gastroesophageal adenocarcinoma (GEA). This is likely caused by the fact that the majority of GEAs, belonging to the chromosomally instable subgroup (70%), are… read more here.
Keywords: suppressive factors; tumor biopsies; secretome freshly; immune suppressive ... See more keywords
Circadian regulator CLOCK recruits immune suppressive microglia into the GBM tumor microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-19-0400
Abstract: Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells (GSCs). Pan-cancer analyses have revealed that stemness of cancer cells correlates positively with immunosuppressive pathways in many solid tumors, including GBM,… read more here.
Keywords: immune suppressive; clock; suppressive microglia; tumor ... See more keywords
Tenascin-C Orchestrates an Immune-Suppressive Tumor Microenvironment in Oral Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-20-0074
Abstract: Tenascin-C, an extracellular matrix protein, contributes to immune suppression in head and neck tumors. Tenascin-C orchestrates immune-suppressive niches by directing spatial distribution of Tregs and myeloid cells, leading to invasive disease. Inherent immune suppression represents… read more here.
Keywords: tenascin; immune suppressive; orchestrates immune; oral squamous ... See more keywords
IDO Vaccine Ablates Immune-Suppressive Myeloid Populations and Enhances Antitumor Effects Independent of Tumor Cell IDO Status
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-21-0457
Abstract: An IDO-specific peptide vaccine is demonstrated to target IDO+ cells, enhancing vaccine-induced immune responses against non-IDO tumor antigens. These effects reduce tumor growth and inhibit immune-suppressive myeloid populations in multiple tumor models. read more here.
Keywords: suppressive myeloid; tumor; myeloid populations; ido ... See more keywords
Abstract A72: IFNAR1 signaling regulates PMN-MDSCs immune suppressive activity in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm18-a72
Abstract: Polymorphnuclear myeloid-derived suppressor cells (PMN-MDSCs) are a subset of MDSCs that are expanded and accumulated in several cancers. The main role of PMN-MDSCs in cancer is the suppression of antitumor immune responses, which leads to… read more here.
Keywords: immune suppressive; pmn mdscs; suppressive activity; cancer ... See more keywords
Targeting Siglec-7: A Novel Immunotherapeutic Approach to Potentiate the Cytotoxic Functions of Natural Killer Cells Against Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.1799.1799
Abstract: Background: MultipleMyeloma (MM) is a malignant plasma cell disorder, accounting for approximately 10% of all haematological malignancies. The intrinsic ability of the malignant cells to evade the host immune system is one of the key… read more here.
Keywords: siglec; immune suppressive; surface; expression ... See more keywords