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   Articles with "immune surveillance" as a keyword



Stem Cells Cycle toward Immune Surveillance.

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recommendations! Published in 2018 at "Immunity"

DOI: 10.1016/j.immuni.2018.02.006

Abstract: Immune surveillance is an established regulatory mechanism that spares tissues from malignant transformation. Agudo et al. (2018) find that the chief cell type to generate tissues in the body-somatic stem cells-is subject to immune surveillance only… read more here.

Keywords: immune surveillance; cells cycle; surveillance; cycle toward ... See more keywords
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Impact of Cancer Evolution on Immune Surveillance and Checkpoint Inhibitor Response.

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recommendations! Published in 2021 at "Seminars in cancer biology"

DOI: 10.1016/j.semcancer.2021.02.013

Abstract: Intratumour heterogeneity (ITH) is pervasive across all cancers studied and may provide the evolving tumour multiple routes to escape immune surveillance. Immune checkpoint inhibitors (CPIs) are rapidly becoming standard of care for many cancers. Here,… read more here.

Keywords: immune surveillance; response; surveillance; checkpoint inhibitor ... See more keywords

Isoxazole-based molecules restore NK cell immune surveillance in hepatocarcinogenesis by targeting TM4SF5 and SLAMF7 linkage

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recommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-024-02106-6

Abstract: Dynamic communication between hepatocytes and the environment is critical in hepatocellular carcinoma (HCC) development. Clinical immunotherapy against HCC is currently unsatisfactory and needs more systemic considerations, including the identification of new biomarkers and immune checkpoints.… read more here.

Keywords: isoxazole; slamf7; tm4sf5; hcc ... See more keywords
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Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-15267-z

Abstract: Microglia are highly motile cells that continuously monitor the brain environment and respond to damage-associated cues. While glucose is the main energy substrate used by neurons in the brain, the nutrients metabolized by microglia to… read more here.

Keywords: immune surveillance; surveillance; flexibility supports; microglial metabolic ... See more keywords

How SARS-CoV-2 dodges immune surveillance and facilitates infection: an analytical review

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recommendations! Published in 2022 at "Expert Review of Anti-infective Therapy"

DOI: 10.1080/14787210.2022.2078307

Abstract: ABSTRACT Introduction Effective treatments for the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are limited. The virus has evolved strategies to evade the immune system or hijack immune responses to facilitate infection and… read more here.

Keywords: review; immune responses; immune surveillance; cov dodges ... See more keywords
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Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells

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recommendations! Published in 2018 at "OncoImmunology"

DOI: 10.1080/2162402x.2017.1364827

Abstract: ABSTRACT Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that… read more here.

Keywords: immune surveillance; tumor cells; platelet mediated; cell immune ... See more keywords

CD80 expression promotes immune surveillance in Barrett’s metaplasia

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recommendations! Published in 2019 at "Oncoimmunology"

DOI: 10.1080/2162402x.2019.1636618

Abstract: ABSTRACT Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell… read more here.

Keywords: barrett metaplasia; immune surveillance; cd80 expression; esophageal carcinogenesis ... See more keywords

Inflammatory β-Cell Stress and Immune Surveillance in Type 1 Diabetes.

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recommendations! Published in 2024 at "Cold Spring Harbor perspectives in medicine"

DOI: 10.1101/cshperspect.a041605

Abstract: Recent years have seen increased recognition for the role of β-cell stress as a contributing factor to the autoimmune destruction process that ultimately results in symptomatic type 1 diabetes (T1D). Preclinical studies have discovered a… read more here.

Keywords: cell stress; stressed cells; immune surveillance; cell ... See more keywords

Immune surveillance in glioblastoma: Role of the NKG2D system and novel cell‐based therapeutic approaches

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recommendations! Published in 2022 at "Scandinavian Journal of Immunology"

DOI: 10.1111/sji.13201

Abstract: Glioblastoma, formerly known as glioblastoma multiforme (GBM), is the most frequent and most aggressive brain tumour in adults. The brain is an immunopriviledged organ, and the blood‐brain barrier shields the brain from immune surveillance. In… read more here.

Keywords: system; glioblastoma; role nkg2d; brain ... See more keywords

PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.ade4186

Abstract: Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) or programmed cell death 1 ligand 1 (PD-L1) have enabled some patients with cancer to experience durable, complete treatment responses; however, reliable anti–PD-(L)1 treatment response… read more here.

Keywords: methylation; k162 methylation; cancer immune; immune surveillance ... See more keywords

Chromosomal chaos silences immune surveillance

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recommendations! Published in 2017 at "Science"

DOI: 10.1126/science.aam5331

Abstract: A high level of chromosomal structural abnormality can suppress the immune response to tumor cells Not all cancers, and not all individuals with the same cancer type, respond equally to immunotherapy—the use of antibodies to… read more here.

Keywords: immune surveillance; surveillance; chaos silences; chromosomal chaos ... See more keywords