Stem Cells Cycle toward Immune Surveillance.
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.02.006
Abstract: Immune surveillance is an established regulatory mechanism that spares tissues from malignant transformation. Agudo et al. (2018) find that the chief cell type to generate tissues in the body-somatic stem cells-is subject to immune surveillance only… read more here.
Keywords: immune surveillance; cells cycle; surveillance; cycle toward ... See more keywords
Impact of Cancer Evolution on Immune Surveillance and Checkpoint Inhibitor Response.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2021.02.013
Abstract: Intratumour heterogeneity (ITH) is pervasive across all cancers studied and may provide the evolving tumour multiple routes to escape immune surveillance. Immune checkpoint inhibitors (CPIs) are rapidly becoming standard of care for many cancers. Here,… read more here.
Keywords: immune surveillance; response; surveillance; checkpoint inhibitor ... See more keywords
Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15267-z
Abstract: Microglia are highly motile cells that continuously monitor the brain environment and respond to damage-associated cues. While glucose is the main energy substrate used by neurons in the brain, the nutrients metabolized by microglia to… read more here.
Keywords: immune surveillance; surveillance; flexibility supports; microglial metabolic ... See more keywords
How SARS-CoV-2 dodges immune surveillance and facilitates infection: an analytical review
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Anti-infective Therapy"
DOI: 10.1080/14787210.2022.2078307
Abstract: ABSTRACT Introduction Effective treatments for the ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are limited. The virus has evolved strategies to evade the immune system or hijack immune responses to facilitate infection and… read more here.
Keywords: review; immune responses; immune surveillance; cov dodges ... See more keywords
Platelet-mediated shedding of NKG2D ligands impairs NK cell immune-surveillance of tumor cells
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1364827
Abstract: ABSTRACT Platelets promote metastasis, among others by coating cancer cells traveling through the blood, which results in protection from NK cell immune-surveillance. The underlying mechanisms, however, remain to be fully elucidated. Here we report that… read more here.
Keywords: immune surveillance; tumor cells; platelet mediated; cell immune ... See more keywords
CD80 expression promotes immune surveillance in Barrett’s metaplasia
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1636618
Abstract: ABSTRACT Esophageal adenocarcinoma (EAC) is the final step of a pathway starting with esophageal reflux disease, Barrett’s metaplasia and Barrett’s dysplasia. Positive costimulatory ligands such as CD80 have been suggested to contribute to anti-tumor T-cell… read more here.
Keywords: barrett metaplasia; immune surveillance; cd80 expression; esophageal carcinogenesis ... See more keywords
Immune surveillance in glioblastoma: Role of the NKG2D system and novel cell‐based therapeutic approaches
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13201
Abstract: Glioblastoma, formerly known as glioblastoma multiforme (GBM), is the most frequent and most aggressive brain tumour in adults. The brain is an immunopriviledged organ, and the blood‐brain barrier shields the brain from immune surveillance. In… read more here.
Keywords: system; glioblastoma; role nkg2d; brain ... See more keywords
PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade4186
Abstract: Immune checkpoint inhibitors targeting programmed cell death protein 1 (PD-1) or programmed cell death 1 ligand 1 (PD-L1) have enabled some patients with cancer to experience durable, complete treatment responses; however, reliable anti–PD-(L)1 treatment response… read more here.
Keywords: methylation; k162 methylation; cancer immune; immune surveillance ... See more keywords
Chromosomal chaos silences immune surveillance
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aam5331
Abstract: A high level of chromosomal structural abnormality can suppress the immune response to tumor cells Not all cancers, and not all individuals with the same cancer type, respond equally to immunotherapy—the use of antibodies to… read more here.
Keywords: immune surveillance; surveillance; chaos silences; chromosomal chaos ... See more keywords
Diminished Immune Surveillance during Histologic Progression of Intraductal Papillary Mucinous Neoplasms Offers a Therapeutic Opportunity for Cancer Interception
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-2585
Abstract: Abstract Purpose: Intraductal papillary mucinous neoplasms (IPMN) are bona fide precursors to pancreatic ductal adenocarcinoma (PDAC). While genomic alterations during multistep IPMN progression have been well cataloged, the accompanying changes within the tumor immune microenvironment… read more here.
Keywords: mucinous neoplasms; progression; immune surveillance; papillary mucinous ... See more keywords
Beyond the Cell Cycle: Enhancing the Immune Surveillance of Tumors Via CDK4/6 Inhibition
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-18-0201
Abstract: Inhibitors of the cyclin-dependent kinases 4 and 6 (CDK4/6) were originally designed to block proliferation and cell cycle progression of cancer cells in which the activity of these kinases is dysregulated. CDK4/6 inhibitors have already… read more here.
Keywords: immune surveillance; cell cycle; cdk4 inhibitors; cancer ... See more keywords