Systems Imaging of the Immune Synapse.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6881-7_25
Abstract: Three-dimensional live cell imaging of the interaction of T cells with antigen-presenting cells (APCs) visualizes the subcellular distributions of signaling intermediates during T cell activation at thousands of resolved positions within a cell. These information-rich… read more here.
Keywords: immune synapse; imaging immune; biology; systems imaging ... See more keywords
Qualitative and quantitative analysis of PMN/T-cell interactions by InFlow and super-resolution microscopy.
Sign Up to like & getrecommendations! Published in 2017 at "Methods"
DOI: 10.1016/j.ymeth.2016.09.013
Abstract: Neutrophils or polymorphonuclear cells (PMN) eliminate bacteria via phagocytosis and/or NETosis. Apart from these conventional roles, PMN also have immune-regulatory functions. They can transdifferentiate and upregulate MHCII as well as ligands for costimulatory receptors which… read more here.
Keywords: immune synapse; microscopy; pmn cell; analysis ... See more keywords
Gp41 dynamically interacts with the TCR in the immune synapse and promotes early T cell activation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28114-5
Abstract: The HIV-1 glycoprotein gp41 critically mediates CD4+ T-cell infection by HIV-1 during viral entry, assembly, and release. Although multiple immune-regulatory activities of gp41 have been reported, the underlying mechanisms of these activities remain poorly understood.… read more here.
Keywords: immune synapse; tcr immune; gp41; gp41 dynamically ... See more keywords
LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118816119
Abstract: Significance Cancers and chronic infectious pathogens often evade immune-mediated elimination by suppressing T cell function via engaging inhibitory receptors expressed on T cells. The phospholipid lysophosphatidic acid (LPA) is often increased systemically from basal concentrations… read more here.
Keywords: immune synapse; function; lpa suppresses; cell function ... See more keywords
CLASP1/2 regulate immune synapse maturation in natural killer cells.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of leukocyte biology"
DOI: 10.1093/jleuko/qiaf138
Abstract: Natural killer (NK) cells are the first line of defense against viral infections and tumors. Their cytotoxic activity relies on the formation of an immune synapse (IS) with target cells. The lymphocyte function-associated antigen (LFA)-1… read more here.
Keywords: killer cells; maturation; immune synapse; natural killer ... See more keywords
Molecular dynamics at immune synapse lipid rafts influence the cytolytic behavior of CAR T cells
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adq8114
Abstract: Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART immune synapse… read more here.
Keywords: caris; cytolytic behavior; lipid rafts; immune synapse ... See more keywords
Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.abp8933
Abstract: Cytotoxic T lymphocytes (CTLs) kill virus-infected and cancer cells through T cell receptor (TCR) recognition. How CTLs terminate signaling and disengage to allow serial killing has remained a mystery. TCR activation triggers membrane specialization within… read more here.
Keywords: immune synapse; ectocytosis; ectocytosis renders; signaling self ... See more keywords
The costimulatory activity of Tim-3 requires Akt and MAPK signaling and its recruitment to the immune synapse
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.aba0717
Abstract: The transmembrane receptor Tim-3 is recruited to the immune synapse of T cells, where it provides costimulatory signals. Stimulating under the right conditions Because the transmembrane receptor Tim-3 is increased in abundance on exhausted T… read more here.
Keywords: receptor; immune synapse; recruitment; tim ... See more keywords
Abstract 1043: Identification of the novel immune synapse-localized proteome for immuno-oncology using Microscoop-induced targeted photo-biotinylation
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1043
Abstract: Although tens of immune synapse (IS) protein species are known, there remain many unknown IS-localized protein species. Understanding the proteome of the IS between a target cell and a lymphocyte is crucial for advancing immuno-oncology.… read more here.
Keywords: oncology; immuno oncology; immune synapse; identification ... See more keywords
Abstract B46: Roles for LKB1 at the immune synapse during B-cell activation and antitumor responses
Sign Up to like & getrecommendations! Published in 2018 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm17-b46
Abstract: Defense from infection or cancer is provided by coordinated actions of the innate and adaptive immune system, including B lymphocytes that generate antibodies (Abs) against pathogens or tumor antigens. B cells establish immune synapses with… read more here.
Keywords: cell activation; immune synapse; cell; tumor ... See more keywords
DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.94298
Abstract: Patients deficient in the guanine nucleotide exchange factor DOCK8 have decreased numbers and impaired in vitro function of Tregs and make autoantibodies, but they seldom develop autoimmunity. We show that, similarly, Dock8-/- mice have decreased… read more here.
Keywords: immune synapse; tregs; immunological tolerance; enforces immunological ... See more keywords