Immune Therapy: What Can We Learn From Acquired Resistance?
Sign Up to like & getrecommendations! Published in 2021 at "Lung Cancer"
DOI: 10.1007/978-3-030-74028-3_5
Abstract: Programmed death-1 (PD-1) pathway inhibitors have revolutionized the treatment of locally advanced and advanced non-small cell lung cancer (NSCLC). Response to these agents can be durable, but most patients will go on to develop resistance… read more here.
Keywords: immune therapy; therapy learn; resistance; acquired resistance ... See more keywords
Organoid technology and applications in cancer immunotherapy and precision medicine.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.05.002
Abstract: Tumors are complex ecosystems of multiple cell types in addition to cancer cells. The response to therapies can be shaped by not only cancer cell vulnerabilities but also by the cells of the tumor microenvironment… read more here.
Keywords: medicine; organoid technology; immune therapy; technology applications ... See more keywords
Fibronectin-Coated Metal-Phenolic Networks for Cooperative Tumor Chemo-/Chemodynamic/Immune Therapy via Enhanced Ferroptosis-Mediated Immunogenic Cell Death.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c08585
Abstract: The development of nanomedicine formulations to overcome the disadvantages of traditional chemotherapeutic drugs and integrate cooperative theranostic modes still remains challenging. Herein, we report the facile construction of a multifunctional theranostic nanoplatform based on doxorubicin… read more here.
Keywords: cell death; immune therapy; therapy; chemo chemodynamic ... See more keywords
Complex interactions between the microbiome and cancer immune therapy
Sign Up to like & getrecommendations! Published in 2019 at "Critical Reviews in Clinical Laboratory Sciences"
DOI: 10.1080/10408363.2019.1660303
Abstract: Abstract Immuno-oncology has rapidly grown in the last thirty years, and immunotherapeutic agents are now approved to treat many disparate cancers. Immune checkpoint inhibitors (ICIs) are employed to augment cytotoxic anti-cancer activity by inhibiting negative… read more here.
Keywords: cancer immune; therapy; immune therapy; colitis ... See more keywords
Biological knowledge graph-guided investigation of immune therapy response in cancer with graph neural network
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad023
Abstract: The determination of transcriptome profiles that mediate immune therapy in cancer remains a major clinical and biological challenge. Despite responses induced by immune-check points inhibitors (ICIs) in diverse tumor types and all the big breakthroughs… read more here.
Keywords: immune therapy; knowledge; graph; response ... See more keywords
Complications associated with immunotherapy for brain metastases.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Neurology"
DOI: 10.1097/wco.0000000000000756
Abstract: PURPOSE OF REVIEW Median survival after the diagnosis of brain metastases has historically been on the order of months. With the recent development of immune checkpoint inhibitors, intracranial activity and durable responses have been observed… read more here.
Keywords: complications associated; neurologic toxicities; immune therapy; associated immunotherapy ... See more keywords
Abstract PL03-03: Taming the beast: Strategies to target the immune-suppressive macrophage to enhance cancer immune therapy
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-pl03-03
Abstract: Advances in basic, translational and clinical research have revealed the power of cancer immune therapy. Checkpoint inhibitors and adoptive T cell therapies are novel, FDA approved therapeutic strategies that promote recruitment to and activation of… read more here.
Keywords: therapy; immune suppressive; immune therapy; cancer ... See more keywords
Abstract SY05-03: Radiomics of immune therapy in NSCLC
Sign Up to like & getrecommendations! Published in 2021 at "Immunology"
DOI: 10.1158/1538-7445.am2021-sy05-03
Abstract: Checkpoint blockade immunotherapy provides improved long-term survival in a subset of advanced stage NSCLC patients. Currently, predictive biomarkers of immunotherapy response are an unmet clinical need. CT and PET/CT images are routinely obtained during workup… read more here.
Keywords: status; radiomics immune; validation; immune therapy ... See more keywords
Abstract B52: KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.ras18-b52
Abstract: The precise biologic functions and mechanisms of oncogenic KrasG12D (Kras*) in therapeutic resistance, including immune therapy, are not understood. Here, utilizing a colorectal cancer (CRC) mouse model engineered with an inducible Kras* transgene and conditional… read more here.
Keywords: therapy; immune therapy; cancer; resistance ... See more keywords
Combination targeted and immune therapy in the treatment of advanced melanoma: a valid treatment option for patients?
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/17588359221090306
Abstract: Melanomas harboring an activating BRAFV600 mutation account for 50% of all advanced melanomas. The approval of BRAF-targeted therapy revolutionized treatment of these patients with achievement of impressive responses. However, development of resistance to these drugs… read more here.
Keywords: advanced melanoma; combination targeted; immune therapy; therapy ... See more keywords
Replication stress response deficiency (RSRD) and response to immune therapy in clear cell renal cell carcinoma (ccRCC).
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.4566
Abstract: 4566Background: Despite treatment advances with immune therapy (IO), advanced stage ccRCC still has poor prognosis, due in part to a lack of predictive biomarkers. Replication stress (RS) is a hall... read more here.
Keywords: ccrcc; response; immune therapy; replication stress ... See more keywords