Tissue‐Targeted Drug Delivery Strategies to Promote Antigen‐Specific Immune Tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202238
Abstract: During autoimmunity or organ transplant rejection, the immune system attacks host or transplanted tissue, causing debilitating inflammation for millions of patients. There is no cure for most of these diseases. Further, available therapies modulate inflammation… read more here.
Keywords: immune tolerance; tolerance; drug delivery; antigen specific ... See more keywords
Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205105
Abstract: Autoimmunity and allergies affect a large number of people across the globe. Current approaches to these diseases target cell types and pathways that drive disease, but these approaches are not cures and cannot differentiate between… read more here.
Keywords: immune tolerance; strategies selective; biomaterial strategies; selective immune ... See more keywords
Inflammasome regulation in driving COVID‐19 severity in humans and immune tolerance in bats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4covhr0221-093rr
Abstract: Coronaviruses (CoVs) are RNA viruses that cause human respiratory infections. Zoonotic transmission of the SARS‐CoV‐2 virus caused the recent COVID‐19 pandemic, which led to over 2 million deaths worldwide. Elevated inflammatory responses and cytotoxicity in… read more here.
Keywords: severity humans; covid severity; immune tolerance; severity ... See more keywords
Immune Tolerance and Rejection in Organ Transplantation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8938-6_12
Abstract: In this chapter, we describe the history of transplantation, the multiple cell types, and mechanisms that are involved in rejection and tolerance of a transplanted organ, as well as summarize the common and promising new… read more here.
Keywords: tolerance rejection; immune tolerance; rejection; transplantation ... See more keywords
Combination of quantitative hepatitis B core antibody (qHBcAb) and aspartate aminotransferase (AST) can accurately diagnose immune tolerance of chronic hepatitis B virus infection based on liver biopsy.
Sign Up to like & getrecommendations! Published in 2020 at "Clinics and research in hepatology and gastroenterology"
DOI: 10.1016/j.clinre.2020.10.008
Abstract: BACKGROUND AND AIMS Immune tolerance is defined as HBeAg positive, high hepatitis B virus load (HBV), persistent normal alanine aminotransferase (ALT), no or slight inflammation or fibrosis in liver histology. However, it is still unclear… read more here.
Keywords: aminotransferase; hepatitis; immune tolerance; ast ... See more keywords
Novel mechanisms in immune tolerance to allergens during natural allergen exposure and allergen-specific immunotherapy.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2017.08.012
Abstract: Allergen-specific immunotherapy (AIT) has been used for more than 100 years as a clinical tolerance-inducing and immune tolerance-inducing therapy for allergic diseases and represents a potentially curative method of treatment. AIT functions through multiple mechanisms… read more here.
Keywords: allergen specific; tolerance; immune tolerance; specific immunotherapy ... See more keywords
New insights into non-conventional epitopes as T cell targets: The missing link for breaking immune tolerance in autoimmune disease?
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.08.001
Abstract: The mechanism by which immune tolerance is breached in autoimmune disease is poorly understood. One possibility is that post-translational modification of self-antigens leads to peripheral recognition of neo-epitopes against which central and peripheral tolerance is… read more here.
Keywords: non conventional; immune tolerance; cell targets; conventional epitopes ... See more keywords
DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2017.09.012
Abstract: Immune tolerance at feto-maternal interfaces is a complex phenomenon. Although maternal decidual macrophages are well-known immune cells, little is known about fetal-derived macrophages (Hofbauer cells) within chorionic villi. Preeclampsia (PE) is a major cause of… read more here.
Keywords: hofbauer cells; immune tolerance; chorionic villi; sign ... See more keywords
Immune Tolerance Induced by Decitabine Combined With Multiple Allogeneic Bone Marrow Mononuclear Cell Infusion.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.05.019
Abstract: OBJECTIVE The aim of our study was to investigate the strategy of immune tolerance induced by the demethylating drug decitabine (DAC) combined with multiple allogeneic bone marrow mononuclear cell (BMMNC) infusions. METHODS An animal model… read more here.
Keywords: immune tolerance; bmmnc group; bmmnc; dac bmmnc ... See more keywords
Tuning surface charges of peptide nanofibers for induction of antigen-specific immune tolerance: an introductory study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2022.01.030
Abstract: Induction of antigen-specific immune tolerance has emerged as the next frontier in treating autoimmune disorders, including atherosclerosis and graft-vs-host reactions during transplantation. Nanostructures are under investigation as a platform for the coordinated delivery of critical… read more here.
Keywords: antigen specific; antigen; peptide nanofibers; specific immune ... See more keywords
Tetrahedral Framework Nucleic Acids Induce Immune Tolerance and Prevent the Onset of Type 1 Diabetes.
Sign Up to like & getrecommendations! Published in 2021 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c01131
Abstract: A failure in immune tolerance leads to autoimmune destruction of insulin-producing β-cells, leading to type 1 diabetes (T1D). Inhibiting autoreactive T cells and inducing regulatory T cells (Tregs) to re-establish immune tolerance are promising approaches… read more here.
Keywords: tolerance; immune tolerance; prevent onset; framework nucleic ... See more keywords