Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury
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DOI: 10.1002/advs.202308978
Abstract: Innate immune training involves myelopoiesis, dynamic gene modulation, and functional reprogramming of myeloid cells in response to secondary heterologous challenges. The present study evaluates whether systemic innate immune training can protect tissues from local injury.… read more here.
Keywords: training; lung injury; injury; immune training ... See more keywords
Ischemia does not provoke the full immune training repertoire in human cardiac fibroblasts
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DOI: 10.1007/s00210-024-03107-6
Abstract: Trained immunity of monocytes, endothelial, and smooth muscle cells augments the cytokine response to secondary stimuli. Immune training is characterized by stabilization of hypoxia-inducible factor (HIF)-1α, mTOR activation, and aerobic glycolysis. Cardiac fibroblast (CF)-myofibroblast transition… read more here.
Keywords: ldh; cardiac fibroblasts; mtor; immune training ... See more keywords