Recapitulating the Cancer‐Immunity Cycle on a Chip
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202401927
Abstract: The cancer‐immunity cycle is a fundamental framework for understanding how the immune system interacts with cancer cells, balancing T cell recognition and elimination of tumors while avoiding autoimmune reactions. Despite advancements in immunotherapy, there remains… read more here.
Keywords: cancer; immunity cycle; chip; cycle ... See more keywords
Extracellular‐Vesicle‐Based Drug Delivery Systems for Enhanced Antitumor Therapies through Modulating the Cancer‐Immunity Cycle
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202201054
Abstract: Although immunotherapy harnessing activity of the immune system against tumors has made great progress, the treatment efficacy remains limited in most cancers. Current anticancer immunotherapy is primarily based on T‐cell‐mediated cellular immunity, which highly relies… read more here.
Keywords: cancer immunity; immunity; immunity cycle; drug delivery ... See more keywords
Activating Iterative Revolutions of the Cancer‐Immunity Cycle in Hypoxic Tumors with a Smart Nano‐Regulator
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DOI: 10.1002/adma.202400196
Abstract: The activation of sequential events in the cancer‐immunity cycle (CIC) is crucial for achieving effective antitumor immunity. However, formidable challenges, such as innate and adaptive immune resistance, along with the off‐target adverse effects of nonselective… read more here.
Keywords: immunity; immunity cycle; hypoxic tumors; immune resistance ... See more keywords
Melanoma Cancer Immunotherapy Using PD-L1 siRNA and Imatinib Promotes Cancer-Immunity Cycle
Sign Up to like & getrecommendations! Published in 2020 at "Pharmaceutical Research"
DOI: 10.1007/s11095-020-02838-4
Abstract: Purpose Cancer-Immunity Cycle is a cascade of anticancer immune responses in the body that continues and fights against the cancer expansion. The Cancer-Immunity Cycle is halted by tumor cell immunosuppression of host T cell through… read more here.
Keywords: immunity; immunity cycle; cancer immunity; cancer ... See more keywords
Symphony of nanomaterials and immunotherapy based on the cancer‒immunity cycle
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.05.031
Abstract: Abstract The immune system is involved in the initiation and progression of cancer. Research on cancer and immunity has contributed to the development of several clinically successful immunotherapies. These immunotherapies often act on a single… read more here.
Keywords: cancer; immunity cycle; cancer immunity; based cancer ... See more keywords
Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.3c08425
Abstract: Effective anticancer immunity depends on properly activating multiple stepwise events in the cancer-immunity cycle. An immunologically "cold" tumor microenvironment (TME) engenders immune evasion and refractoriness to conventional checkpoint blockade immunotherapy. Here, we combine nanoparticle formulations… read more here.
Keywords: cancer; immunity; immunity cycle; immunogenic hydrogel ... See more keywords
Abstract 1033: NANOG-HSP90A axis confers immunotherapeutic resistance by blocking anti-tumor immunity cycle
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-1033
Abstract: T cell-based immunotherapy has shifted the paradigm for cancer treatment. However, the majority of patients lack effective responses due to presence of immune-refractory tumor cells that limits its clinical success by blocking amplification of anti-tumor… read more here.
Keywords: hsp90a; tumor immunity; anti tumor; immunity cycle ... See more keywords
Combination therapy with lipid prodrug liposomes reshapes disease-associated neutrophils to promote the cancer-immunity cycle
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-025-03179-3
Abstract: Neutrophils play a critical role in the cancer-immunity cycle and are associated with poor clinical outcomes. Recent research has primarily focused on the targeted delivery, phenotypic reversal, and reprogramming of tumor-associated neutrophils, while the impact… read more here.
Keywords: combination therapy; therapy; associated neutrophils; immunity cycle ... See more keywords
Comprehensive Analysis of a Cancer-Immunity Cycle–Based Signature for Predicting Prognosis and Immunotherapy Response in Patients With Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.892512
Abstract: Immune checkpoint blockade (ICB) has been recognized as a promising immunotherapy for colorectal cancer (CRC); however, most patients have little or no clinical benefit. This study aimed to develop a novel cancer-immunity cycle–based signature to… read more here.
Keywords: immunotherapy; cancer immunity; immunity cycle; cancer ... See more keywords
Comprehending the cuproptosis and cancer-immunity cycle network: delving into the immune landscape and its predictive role in breast cancer immunotherapy responses and clinical endpoints
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1344023
Abstract: Background The role of cuproptosis, a phenomenon associated with tumor metabolism and immunological identification, remains underexplored, particularly in relation to the cancer-immunity cycle (CIC) network. This study aims to rigorously examine the impact of the… read more here.
Keywords: cancer; breast cancer; immunity cycle; cuproptosis ... See more keywords
Circadian and Immunity Cycle Talk in Cancer Destination: From Biological Aspects to In Silico Analysis
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DOI: 10.3390/cancers14061578
Abstract: Simple Summary The circadian cycle is a natural cycle of the body repeated every 24 h, based on a day and night rhythm, and it affects many body processes. The present article reviews the importance… read more here.
Keywords: cycle; circadian cycle; circadian immunity; immunity cycle ... See more keywords