Targeting the immunity protein kinases for immuno-oncology.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.072
Abstract: With the rise of immuno-oncology, small-molecule modulators targeting immune system and inflammatory processes are becoming a research hotspot. This work mainly focuses on key kinases acting as central nodes in immune signaling pathways. Although over… read more here.
Keywords: immunity protein; oncology; protein kinases; immuno oncology ... See more keywords
Molecular Basis for Immunity Protein Recognition of a Type VII Secretion System Exported Antibacterial Toxin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2018.08.027
Abstract: Gram-positive bacteria deploy the type VII secretion system (T7SS) to facilitate interactions between eukaryotic and prokaryotic cells. In recent work, we identified the TelC protein from Streptococcus intermedius as a T7SS-exported lipid II phosphatase that… read more here.
Keywords: vii secretion; secretion system; telc; immunity protein ... See more keywords
Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26041-0
Abstract: While the major virulence factors for Vibrio cholerae, the cause of the devastating diarrheal disease cholera, have been extensively studied, the initial intestinal colonization of the bacterium is not well understood because non-human adult animals… read more here.
Keywords: gut; commensal; type secretion; immunity protein ... See more keywords