Health‐related quality‐of‐life assessment of patients with solid tumors on immuno‐oncology therapies
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DOI: 10.1002/cncr.33457
Abstract: Immuno‐oncology therapies have been approved for various solid tumors; however, the high cost of these treatments and their potential toxicities require a thorough assessment of their risks and benefits. Collection of data directly from patients… read more here.
Keywords: solid tumors; immuno oncology; health related; oncology therapies ... See more keywords
Quantitative Translation in Immuno‐Oncology Research and Development
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DOI: 10.1002/cpt.1936
Abstract: Harnessing the full therapeutic potential of the explosively growing universe of immuno-oncology (IO) drug targets and diverse therapeutic modalities in a highly competitive clinical research landscape demands commitment to principled decisions through biologically sound quantitative… read more here.
Keywords: research; immuno oncology; quantitative translation; oncology ... See more keywords
Special Issue on Single‐Cell Multiomics for Immuno‐Oncology and Cancer Systems Biology
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DOI: 10.1002/pmic.201900235
Abstract: Proteomics is inviting submissions to a special issue on singlecell multiomics for immuno-oncology and cancer systems biology. This issue is tentatively scheduled for publication in spring/summer 2020. Recent advances in cancer immunotherapies have provided paradigm… read more here.
Keywords: single cell; immuno oncology; biology; cancer ... See more keywords
Immuno-oncology for Gynecologic Malignancies.
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DOI: 10.1007/978-3-030-41008-7_7
Abstract: Patients with advanced and/or recurrent gynecologic cancers derive limited benefit from currently available cytotoxic and targeted therapies. Successes of immunotherapy in other difficult-to-treat malignancies such as metastatic melanoma and advanced lung cancer have led to… read more here.
Keywords: gynecologic cancers; immuno oncology; oncology gynecologic; cancer ... See more keywords
Concepts in immuno-oncology: tackling B cell malignancies with CD19-directed bispecific T cell engager therapies
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DOI: 10.1007/s00277-020-04221-0
Abstract: The B cell surface antigen CD19 is a target for treating B cell malignancies, such as B cell precursor acute lymphoblastic leukemia and B cell non-Hodgkin lymphoma. The BiTE® immuno-oncology platform includes blinatumomab, which is… read more here.
Keywords: bispecific cell; cell malignancies; immuno oncology; cell engager ... See more keywords
Modelling the Survival Outcomes of Immuno-Oncology Drugs in Economic Evaluations: A Systematic Approach to Data Analysis and Extrapolation
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DOI: 10.1007/s40273-017-0558-5
Abstract: BackgroundNew immuno-oncology (I-O) therapies that harness the immune system to fight cancer call for a re-examination of the traditional parametric techniques used to model survival from clinical trial data. More flexible approaches are needed to… read more here.
Keywords: immuno oncology; analysis; approach data; systematic approach ... See more keywords
Estimating Lifetime Benefits Associated with Immuno-Oncology Therapies: Challenges and Approaches for Overall Survival Extrapolations
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DOI: 10.1007/s40273-019-00806-4
Abstract: BackgroundStandard parametric survival models are commonly used to estimate long-term survival in oncology health technology assessments; however, they can inadequately represent the complex pattern of hazard functions or underlying mechanism of action (MoA) of immuno-oncology… read more here.
Keywords: estimating lifetime; immuno oncology; overall survival; oncology ... See more keywords
Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo.
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DOI: 10.1016/j.canlet.2018.10.020
Abstract: Phosphoinositide 3-kinase gamma isoform (PI3Kγ) plays a critical role in myeloid-derived cells of the immunosuppressive tumor microenvironment. IPI-549, a recently discovered small molecule selective PI3Kγ inhibitor, is currently under immuno-oncology clinical trials in combination with… read more here.
Keywords: immuno oncology; mdr; sw620 ad300; ipi 549 ... See more keywords
Immuno-Oncology beyond TILs: Unleashing TILCs.
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DOI: 10.1016/j.ccell.2020.03.021
Abstract: Innate lymphoid cells (ILCs) are detected in multiple tumor types, but their contribution to tumor immunity remains unclear. Moral et al. show that a subset of tumor ILCs (TILCs) may participate in an organ-specific immune response… read more here.
Keywords: oncology beyond; immuno oncology; tilcs; beyond tils ... See more keywords
Models for Immuno-oncology Research.
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DOI: 10.1016/j.ccell.2020.07.010
Abstract: The interactions between cancer cells and immune cells are complex and context dependent. Choosing the right model to study these interactions is a crucial step in the development of immunotherapies. From cell co-cultures to organoids,… read more here.
Keywords: models immuno; oncology; oncology research; immuno oncology ... See more keywords
Developing and validating model systems for immuno-oncology.
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DOI: 10.1016/j.ccell.2021.05.017
Abstract: Owing to clinical success of immune-checkpoint blockade, immunotherapy is becoming a cornerstone of modern oncology, and immuno-oncology is at the forefront of basic cancer research. This commentary outlines future opportunities for immuno-oncology modeling. read more here.
Keywords: validating model; model systems; immuno oncology; systems immuno ... See more keywords