Personalizing NSCLC therapy by characterizing tumors using TKI-PET and immuno-PET.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2016.05.025
Abstract: Non-small cell lung cancer (NSCLC) therapy has entered a rapidly advancing era of precision medicine with an ever increasing number of drugs directed against a variety of specific tumor targets. Amongst these new agents, tyrosine… read more here.
Keywords: pet; tki pet; immuno pet; personalizing nsclc ... See more keywords
Photoradiosynthesis of 68Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00342
Abstract: In an alternative approach for radiotracer design, a photoactivatable HBED-CC-PEG3-ArN3 chelate was synthesized and photoconjugated to the anti-c-MET antibody MetMAb (onartuzumab). Photoconjugation gave the functionalized protein HBED-CC-azepin-MetMAb with a photochemical conversion of 18.5 ± 0.5%… read more here.
Keywords: photoradiosynthesis 68ga; metmab; immuno pet; hbed azepin ... See more keywords
Immuno-PET Imaging and Radioimmunotherapy of Lymphomas.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00563
Abstract: Monoclonal antibodies (Ab) have revolutionized the management of lymphomas, the most common hematologic malignancy in adults. Indeed, incorporation of rituximab into the regimen for indolent non-Hodgkin's lymphomas (NHLs) has dramatically improved treatment response and disease… read more here.
Keywords: pet; immuno pet; lymphomas; radioimmunotherapy ... See more keywords
Preclinical Research Highlighting Contemporary Targeting Mechanisms of Radiolabelled Compounds for PET Based Infection Imaging.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in nuclear medicine"
DOI: 10.1053/j.semnuclmed.2023.03.001
Abstract: It is important to constantly monitor developments in the preclinical imaging arena of infection. Firstly, novel radiopharmaceuticals with the correct characteristics must be identified to funnel into the clinic. Secondly, it must be evaluated if… read more here.
Keywords: infection; immuno pet; infection imaging; medicine ... See more keywords
Development of a Theranostic Convergence Bioradiopharmaceutical for Immuno-PET Based Radioimmunotherapy of L1CAM in Cholangiocarcinoma Model
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1157
Abstract: Purpose: Cholangiocarcinoma is a malignancy of bile duct with a poor prognosis. Conventional chemotherapy and radiotherapy are generally ineffective, and surgical resection is the only curative treatment for cholangiocarcinoma. L1-cell adhesion molecule (L1CAM) has been… read more here.
Keywords: cholangiocarcinoma; l1cam; immuno pet; ca10 ... See more keywords
Immuno-PET monitoring of lymphocytes using the CD8-specific antibody REGN5054.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0405
Abstract: Assessment of immune-cell subsets within the tumor immune microenvironment is a powerful approach to better understand cancer immunotherapy responses. However, the use of biopsies to assess the tumor immune microenvironment poses challenges, including the potential… read more here.
Keywords: cell; regn5054; immuno pet; antibody ... See more keywords
Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody
Sign Up to like & getrecommendations! Published in 2018 at "EJNMMI Research"
DOI: 10.1186/s13550-018-0358-8
Abstract: BackgroundIdeally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development. However, the imaging signal consists of specific, as… read more here.
Keywords: mediated uptake; immuno pet; antibody; anti cd44 ... See more keywords
Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example
Sign Up to like & getrecommendations! Published in 2021 at "EJNMMI Research"
DOI: 10.1186/s13550-021-00813-7
Abstract: Background 89 Zirconium-immuno-positron emission tomography ( 89 Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target concentration to improve future… read more here.
Keywords: immuno pet; trastuzumab; example; target ... See more keywords
Advances in Immuno-PET in the Detection of Cancer and Assessment of Response to Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200128102958
Abstract: BACKGROUND Monoclonal antibodies (mAbs) against tumor-associated antigens have been shown to target tumors with specificity and selectivity; therefore, it was hypothesized that cancer could be treated with mAbs without side effects. In the early 1980s,… read more here.
Keywords: response; immuno pet; pet detection; cancer ... See more keywords
Immuno-PET Imaging to Assess Target Engagement: Experience from 89Zr-Anti-HER3 mAb (GSK2849330) in Patients with Solid Tumors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Nuclear Medicine"
DOI: 10.2967/jnumed.118.214726
Abstract: PET imaging with radiolabeled drugs provides information on tumor uptake and dose-dependent target interaction to support selection of an optimal dose for future efficacy testing. In this immuno-PET study of the anti–human epidermal growth factor… read more here.
Keywords: target engagement; immuno pet; target; mab ... See more keywords
Immuno-PET: Design options and clinical proof-of-concept
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1026083
Abstract: Radioimmunoconjugates have been used for over 30 years in nuclear medicine applications. In the last few years, advances in cancer biology knowledge have led to the identification of new molecular targets specific to certain patient… read more here.
Keywords: design options; immuno pet; nuclear medicine; medicine ... See more keywords