Investigation of the Impact of the H310A FcRn Region Mutation on 89Zr-Immuno-PET Brain Imaging with a BBB-Shuttle Anti‑Amyloid Beta Antibody
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-024-01931-z
Abstract: In the emerging field of antibody treatments for neurodegenerative diseases, reliable tools are needed to evaluate new therapeutics, diagnose and select patients, monitor disease progression, and assess therapy response. Immuno-PET combines the high affinity and… read more here.
Keywords: immuno pet; brain; brain imaging; amyloid beta ... See more keywords
Personalizing NSCLC therapy by characterizing tumors using TKI-PET and immuno-PET.
Sign Up to like & getrecommendations! Published in 2017 at "Lung cancer"
DOI: 10.1016/j.lungcan.2016.05.025
Abstract: Non-small cell lung cancer (NSCLC) therapy has entered a rapidly advancing era of precision medicine with an ever increasing number of drugs directed against a variety of specific tumor targets. Amongst these new agents, tyrosine… read more here.
Keywords: pet; tki pet; immuno pet; personalizing nsclc ... See more keywords
Photoradiosynthesis of 68Ga-Labeled HBED-CC-Azepin-MetMAb for Immuno-PET of c-MET Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00342
Abstract: In an alternative approach for radiotracer design, a photoactivatable HBED-CC-PEG3-ArN3 chelate was synthesized and photoconjugated to the anti-c-MET antibody MetMAb (onartuzumab). Photoconjugation gave the functionalized protein HBED-CC-azepin-MetMAb with a photochemical conversion of 18.5 ± 0.5%… read more here.
Keywords: photoradiosynthesis 68ga; metmab; immuno pet; hbed azepin ... See more keywords
Immuno-PET Imaging and Radioimmunotherapy of Lymphomas.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00563
Abstract: Monoclonal antibodies (Ab) have revolutionized the management of lymphomas, the most common hematologic malignancy in adults. Indeed, incorporation of rituximab into the regimen for indolent non-Hodgkin's lymphomas (NHLs) has dramatically improved treatment response and disease… read more here.
Keywords: pet; immuno pet; lymphomas; radioimmunotherapy ... See more keywords
Preclinical Research Highlighting Contemporary Targeting Mechanisms of Radiolabelled Compounds for PET Based Infection Imaging.
Sign Up to like & getrecommendations! Published in 2023 at "Seminars in nuclear medicine"
DOI: 10.1053/j.semnuclmed.2023.03.001
Abstract: It is important to constantly monitor developments in the preclinical imaging arena of infection. Firstly, novel radiopharmaceuticals with the correct characteristics must be identified to funnel into the clinic. Secondly, it must be evaluated if… read more here.
Keywords: infection; immuno pet; infection imaging; medicine ... See more keywords
Development of a Theranostic Convergence Bioradiopharmaceutical for Immuno-PET Based Radioimmunotherapy of L1CAM in Cholangiocarcinoma Model
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1157
Abstract: Purpose: Cholangiocarcinoma is a malignancy of bile duct with a poor prognosis. Conventional chemotherapy and radiotherapy are generally ineffective, and surgical resection is the only curative treatment for cholangiocarcinoma. L1-cell adhesion molecule (L1CAM) has been… read more here.
Keywords: cholangiocarcinoma; l1cam; immuno pet; ca10 ... See more keywords
Immuno-PET monitoring of lymphocytes using the CD8-specific antibody REGN5054.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0405
Abstract: Assessment of immune-cell subsets within the tumor immune microenvironment is a powerful approach to better understand cancer immunotherapy responses. However, the use of biopsies to assess the tumor immune microenvironment poses challenges, including the potential… read more here.
Keywords: cell; regn5054; immuno pet; antibody ... See more keywords
Assessment of target-mediated uptake with immuno-PET: analysis of a phase I clinical trial with an anti-CD44 antibody
Sign Up to like & getrecommendations! Published in 2018 at "EJNMMI Research"
DOI: 10.1186/s13550-018-0358-8
Abstract: BackgroundIdeally, monoclonal antibodies provide selective treatment by targeting the tumour, without affecting normal tissues. Therefore, antibody imaging is of interest, preferably in early stages of drug development. However, the imaging signal consists of specific, as… read more here.
Keywords: mediated uptake; immuno pet; antibody; anti cd44 ... See more keywords
Potential and pitfalls of 89Zr-immuno-PET to assess target status: 89Zr-trastuzumab as an example
Sign Up to like & getrecommendations! Published in 2021 at "EJNMMI Research"
DOI: 10.1186/s13550-021-00813-7
Abstract: Background 89 Zirconium-immuno-positron emission tomography ( 89 Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target concentration to improve future… read more here.
Keywords: immuno pet; trastuzumab; example; target ... See more keywords
Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET
Sign Up to like & getrecommendations! Published in 2024 at "EJNMMI Research"
DOI: 10.1186/s13550-024-01079-5
Abstract: Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89Zr-mAb uptake on PET. Target-specific binding in tumours is of main interest; however, non-specific irreversible uptake may also be present,… read more here.
Keywords: immuno pet; 89zr immuno; target negative; negative tumours ... See more keywords
Advances in Immuno-PET in the Detection of Cancer and Assessment of Response to Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Current medicinal chemistry"
DOI: 10.2174/0929867327666200128102958
Abstract: BACKGROUND Monoclonal antibodies (mAbs) against tumor-associated antigens have been shown to target tumors with specificity and selectivity; therefore, it was hypothesized that cancer could be treated with mAbs without side effects. In the early 1980s,… read more here.
Keywords: response; immuno pet; pet detection; cancer ... See more keywords