Antigen discovery and specification of immunodominance hierarchies for MHCII-restricted epitopes
Sign Up to like & getrecommendations! Published in 2018 at "Nature Medicine"
DOI: 10.1038/s41591-018-0203-7
Abstract: Identifying immunodominant T cell epitopes remains a significant challenge in the context of infectious disease, autoimmunity, and immuno-oncology. To address the challenge of antigen discovery, we developed a quantitative proteomic approach that enabled unbiased identification… read more here.
Keywords: antigen discovery; immunodominance; restricted epitopes; cell ... See more keywords
Antigenic sites in influenza H1 hemagglutinin display species-specific immunodominance
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci122895
Abstract: Hemagglutination inhibition (HI) titers are a major correlate of protection for influenza-related illness. The influenza virus hemagglutinin possesses antigenic sites that are the targets of HI active antibodies. Here, a panel of mutant viruses each… read more here.
Keywords: immunodominance; antigenic sites; species specific; hemagglutinin ... See more keywords
A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010248
Abstract: Many SARS-CoV-2 variants have mutations at key sites targeted by antibodies. However, it is unknown if antibodies elicited by infection with these variants target the same or different regions of the viral spike as antibodies… read more here.
Keywords: cov variant; variant elicits; immunodominance; elicits antibody ... See more keywords