Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.04.054
Abstract: Highlights • VRC01 epitope focused structure-based immunogen design.• Gp120 outer-domain core was further stabilized by 375 tryptophan substitution.• Epitope specific antibodies were predominately induced through guinea pig immunizations. read more here.
Keywords: gp120; domain core; outer domain; immunogen design ... See more keywords
What Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise.
Sign Up to like & getrecommendations! Published in 2017 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a030262
Abstract: Functional antibodies, i.e., those with antipathogen activity in in vitro assays, are generally the best correlate of vaccine protection. Mimics of natural infection, including live attenuated and killed pathogens, which induce such antibodies in vivo,… read more here.
Keywords: functional antibodies; design vaccine; immunogen design; powerful immunogen ... See more keywords