Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis.
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DOI: 10.1073/pnas.2209973120
Abstract: Obesity is a major risk factor for cancer. Conventional thought suggests that elevated adiposity predisposes to heightened inflammatory stress and potentiates tumor growth, yet underlying mechanisms remain ill-defined. Here, we show that tumors from patients… read more here.
Keywords: immunogenic malignancies; poorly immunogenic; senescence; obesity ... See more keywords