Immunogenicity Rates After SARS-CoV-2 Vaccination in People With End-stage Kidney Disease
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.31749
Abstract: Key Points Question What are the immunogenicity rates in people with end-stage kidney disease receiving SARS-CoV-2 vaccines? Findings This systematic review and meta-analysis of 32 studies found that patients receiving dialysis had lower immunogenicity rates… read more here.
Keywords: stage kidney; immunogenicity; immunogenicity rates; vaccination ... See more keywords
Long-term Immunogenicity of BNT162b2 Vaccine in Patients With Solid Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.1467
Abstract: Long-term Immunogenicity of BNT162b2 Vaccine in Patients With Solid Tumors In a previous cohort study, administration of the BNT162b2 vaccine in patients with solid tumors demonstrated a favorable safety and efficacy profile following the second… read more here.
Keywords: patients solid; vaccine patients; immunogenicity; solid tumors ... See more keywords
Reversing epigenetic repression of transposable elements for improving tumor immunogenicity
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DOI: 10.1002/cac2.12261
Abstract: In a recent study published in Nature, Zhang et al. [1] revealed a new epigenetic mechanism for restraining tumor intrinsic immunogenicity: Lysine demethylase 5B (KDM5B) recruits SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) to… read more here.
Keywords: transposable elements; repression; immunogenicity; reversing epigenetic ... See more keywords
Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200434
Abstract: Many pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting that pathogen immunogenicity can be chemically enhanced. Using supramolecular host‐guest chemistry, we complexed onto… read more here.
Keywords: bacteria supramolecular; chemically enhanced; enhanced immunogenicity; immunogenicity ... See more keywords
Comparative Pharmacokinetics, Safety, and Immunogenicity Study of the Prefilled Syringe and Lyophilized Formulation of a Recombinant Human Tumor Necrosis Factor‐α Receptor II:lgG Fc Fusion Protein in Healthy Chinese Male Subjects
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1091
Abstract: This study aimed to compare the pharmacokinetics, safety, and immunogenicity of the prefilled syringe (PFS) with lyophilized (LYO) recombinant human tumor necrosis factor‐α receptor II:lgG Fc fusion protein (rhTNFR:Fc) in healthy Chinese male subjects. A… read more here.
Keywords: safety; chinese male; healthy chinese; immunogenicity ... See more keywords
Changes in Manufacturing Processes of Biologic Therapies Can Alter the Immunogenicity Profile of the Product
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1694
Abstract: Manufacturing process changes may alter the characteristics of a protein therapeutic. In 2009, somatropin (version 1.0), a recombinant human growth hormone therapeutic, underwent a manufacturing update (version 1.1). The immunogenicity of somatropin version 1.1 as… read more here.
Keywords: changes manufacturing; version; immunogenicity; somatropin version ... See more keywords
Stromal Cells Act as Guardians for Endothelial Progenitors by Reducing Their Immunogenicity After Co‐Transplantation
Sign Up to like & getrecommendations! Published in 2017 at "STEM CELLS"
DOI: 10.1002/stem.2573
Abstract: Regeneration of injured tissues requires effective therapeutic strategies supporting vasculogenesis. The lack of instantly available autologous cell sources and immunogenicity of allogeneic endothelial (progenitor) cells limits clinical progress. Based on the immunosuppressive potency of mesenchymal… read more here.
Keywords: ecfcs mscs; immunogenicity; vasculogenesis; transplantation ... See more keywords
Decreasing the immunogenicity of Erwinia chrysanthemi asparaginase via protein engineering: computational approach
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04921-5
Abstract: Immunogenicity of therapeutic proteins is one of the main challenges in disease treatment. l-Asparaginase is an important enzyme in cancer treatment which sometimes leads to undesirable side effects such as immunogenic or allergic responses. Here,… read more here.
Keywords: protein; erwinia chrysanthemi; immunogenicity; chrysanthemi asparaginase ... See more keywords
Characterization and immunogenicity of bone marrow-derived mesenchymal stem cells under osteoporotic conditions
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DOI: 10.1007/s11427-019-1555-9
Abstract: Mesenchymal stem cells (MSCs) are characterized by their multilineage potential and low immunogenicity. However, the properties of MSCs under pathological conditions are unclear. The current study investigated the differentiation potential and immunological characteristics of bone… read more here.
Keywords: immunogenicity; mesenchymal stem; stem cells; bmscs ... See more keywords
Product-Related Factors and Immunogenicity of Biotherapeutics
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DOI: 10.1007/s12247-019-09423-2
Abstract: Purpose Biologic molecules constitute a major part of the therapeutics portfolio across the pipeline of several biotech and pharmaceutical companies. They have the advantage of being more target-specific, and recent progress in protein engineering has… read more here.
Keywords: risk; immunogenicity; product related; product ... See more keywords
Immunogenicity of Botulinum Toxin Formulations: Potential Therapeutic Implications
Sign Up to like & getrecommendations! Published in 2021 at "Advances in Therapy"
DOI: 10.1007/s12325-021-01882-9
Abstract: Botulinum neurotoxins (BoNTs) are proteins produced by bacteria of the Clostridium family. Upon oral ingestion, BoNT causes the neuroparalytic syndrome botulism. There are seven serotypes of BoNT (serotypes A-G); BoNT-A and BoNT-B are the botulinum… read more here.
Keywords: immunogenicity; treatment; bont; botulinum ... See more keywords