Immunogenicity Rates After SARS-CoV-2 Vaccination in People With End-stage Kidney Disease
Sign Up to like & getrecommendations! Published in 2021 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.31749
Abstract: Key Points Question What are the immunogenicity rates in people with end-stage kidney disease receiving SARS-CoV-2 vaccines? Findings This systematic review and meta-analysis of 32 studies found that patients receiving dialysis had lower immunogenicity rates… read more here.
Keywords: stage kidney; immunogenicity; immunogenicity rates; vaccination ... See more keywords
Long-term Immunogenicity of BNT162b2 Vaccine in Patients With Solid Tumors.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.1467
Abstract: Long-term Immunogenicity of BNT162b2 Vaccine in Patients With Solid Tumors In a previous cohort study, administration of the BNT162b2 vaccine in patients with solid tumors demonstrated a favorable safety and efficacy profile following the second… read more here.
Keywords: patients solid; vaccine patients; immunogenicity; solid tumors ... See more keywords
Reversing epigenetic repression of transposable elements for improving tumor immunogenicity
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Communications"
DOI: 10.1002/cac2.12261
Abstract: In a recent study published in Nature, Zhang et al. [1] revealed a new epigenetic mechanism for restraining tumor intrinsic immunogenicity: Lysine demethylase 5B (KDM5B) recruits SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) to… read more here.
Keywords: transposable elements; repression; immunogenicity; reversing epigenetic ... See more keywords
Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200434
Abstract: Many pathogens blunt immune responses because they lack immunogenic structural features, which typically results in disease. Here, we show evidence suggesting that pathogen immunogenicity can be chemically enhanced. Using supramolecular host‐guest chemistry, we complexed onto… read more here.
Keywords: bacteria supramolecular; chemically enhanced; enhanced immunogenicity; immunogenicity ... See more keywords
Comparative Pharmacokinetics, Safety, and Immunogenicity Study of the Prefilled Syringe and Lyophilized Formulation of a Recombinant Human Tumor Necrosis Factor‐α Receptor II:lgG Fc Fusion Protein in Healthy Chinese Male Subjects
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1091
Abstract: This study aimed to compare the pharmacokinetics, safety, and immunogenicity of the prefilled syringe (PFS) with lyophilized (LYO) recombinant human tumor necrosis factor‐α receptor II:lgG Fc fusion protein (rhTNFR:Fc) in healthy Chinese male subjects. A… read more here.
Keywords: safety; chinese male; healthy chinese; immunogenicity ... See more keywords
Changes in Manufacturing Processes of Biologic Therapies Can Alter the Immunogenicity Profile of the Product
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.1694
Abstract: Manufacturing process changes may alter the characteristics of a protein therapeutic. In 2009, somatropin (version 1.0), a recombinant human growth hormone therapeutic, underwent a manufacturing update (version 1.1). The immunogenicity of somatropin version 1.1 as… read more here.
Keywords: changes manufacturing; version; immunogenicity; somatropin version ... See more keywords
IQ Survey Results on Current Industry Practices—Part 1: Immunogenicity Risk Assessment
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3568
Abstract: An immunogenicity risk assessment (IRA) is a relatively new expectation of health authorities that is increasingly incorporated into the drug development process across the pharmaceutical/biotech industry. The guiding principle for an IRA includes a comprehensive… read more here.
Keywords: survey; immunogenicity; pharmacology; risk ... See more keywords
Nonclinical safety and immunogenicity assessment of a combined DTacP vaccine in animal models
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4668
Abstract: The (diphtheria, tetanus, and pertussis [acellular, component] [DTacP]) vaccine is a combined vaccine designed to prevent three potentially fatal diseases including pertussis, tetanus, and diphtheria in both children and adults. We utilized advanced technology to… read more here.
Keywords: dtacp vaccine; animal models; vaccine animal; vaccine ... See more keywords
Rational prediction of immunogenicity clustering through cross‐reactivity analysis of thirteen SARS‐CoV‐2 variants
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29314
Abstract: SARS‐CoV‐2 breakthrough infections in vaccinated individuals underscore the threat posed by continuous mutating variants, such as Omicron, to vaccine‐induced immunity. This necessitates the search for broad‐spectrum immunogens capable of countering infections from such variants. This… read more here.
Keywords: sars cov; rational prediction; cov variants; d614g xbb ... See more keywords
Validation of a triple‐color pseudovirion‐based neutralization assay for immunogenicity assessment of a 14‐valent recombinant human papillomavirus vaccine
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29859
Abstract: Validation of bioanalytical methods is crucial, especially in the pharmaceutical industry, to determine their suitability for specific purposes and the accuracy of analytical results. The pseudovirion‐based neutralization assay (PBNA) is considered the gold standard for… read more here.
Keywords: pseudovirion based; human papillomavirus; triple color; vaccine ... See more keywords
The Immunogenicity of Coxsackievirus A6 (D3a Sub‐Genotype) Virus‐Like Particle and mRNA Vaccines
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70201
Abstract: In recent years, coxsackievirus A6 (CVA6) has surpassed enterovirus A71 to become the main pathogen causing severe Hand, Foot, and Mouth disease (HFMD) in China with a substantial disease burden. However, there is currently no… read more here.
Keywords: sub genotype; d3a; mrna vaccines; immunogenicity ... See more keywords