Unconventional Approaches to Modulating the Immunogenicity of Tumor Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in cancer research"
DOI: 10.1016/bs.acr.2017.11.004
Abstract: For several years, it has been known that histone deacetylase inhibitors have the potential to alter the immunogenicity of tumor cells exposed to checkpoint inhibitory immunotherapy antibodies. HDAC inhibitors can rapidly reduce expression of PD-L1… read more here.
Keywords: immunogenicity; tumor cells; immunogenicity tumor; expression ... See more keywords
CD8+ TILs in NSCLC differentiate into TEMRA via a bifurcated trajectory: deciphering immunogenicity of tumor antigens
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DOI: 10.1136/jitc-2021-002709
Abstract: Background CD8+ tumor-infiltrating lymphocytes (TILs) comprise phenotypically and functionally heterogeneous subpopulations. Of these, effector memory CD45RA re-expressing CD8+ T cells (Temra) have been discovered and characterized as the most terminally differentiated subset. However, their exact… read more here.
Keywords: cd8; tumor antigens; immunogenicity tumor; cd8 tils ... See more keywords
Abstract 4722: 4SC-202 increases immunogenicity of tumor cells, induces infiltration of tumor microenvironment with cytotoxic T cells, and primes tumors for combinations with different cancer immunotherapy approaches
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4722
Abstract: Various histone deacetylases (HDAC) inhibitors were described as beneficially affecting anti-tumoral immune response. Although different HDAC inhibitors were investigated in syngeneic tumor models, their mode of anti-tumoral action (MOA) is not yet fully understood. Here,… read more here.
Keywords: 4sc 202; tumor cells; immunogenicity tumor; cancer ... See more keywords