Immunoglobulin Light Chain Amyloidosis: 2022 Update on Diagnosis, Prognosis, and Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of hematology"
DOI: 10.1002/ajh.26569
Abstract: DISEASE OVERVIEW Immunoglobulin light chain amyloidosis is a clonal, nonproliferative plasma cell disorder in which fragments of immunoglobulin light or heavy chain are deposited in tissues. Clinical features depend on organs involved but can include… read more here.
Keywords: diagnosis; immunoglobulin light; light; light chain ... See more keywords
Assessment of prognosis in immunoglobulin light chain amyloidosis patients with severe heart failure: a predictive value of right ventricular function
Sign Up to like & getrecommendations! Published in 2019 at "Heart and Vessels"
DOI: 10.1007/s00380-019-01513-y
Abstract: Although the benefit of updated therapeutic regimens, including bortezomib, on the survival of immunoglobulin light chain (AL) amyloidosis patients with heart failure (HF) has been reported, predictors of mortality in the patients treated with the… read more here.
Keywords: patients severe; heart; immunoglobulin light; amyloidosis ... See more keywords
Focused review on nutritional status of patients with immunoglobulin light chain amyloidosis.
Sign Up to like & getrecommendations! Published in 2022 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2021.100833
Abstract: BACKGROUND Immunoglobulin light chain (AL) amyloidosis is a complex disease marked by a poor clinical portrait and prognosis generally leading to organ dysfunction and shortened survival. We aimed to review the available evidence on whether… read more here.
Keywords: light chain; chain amyloidosis; immunoglobulin light; nutritional status ... See more keywords
Oxidative Post-Translational Modifications of an Amyloidogenic Immunoglobulin Light Chain Protein.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of mass spectrometry"
DOI: 10.1016/j.ijms.2016.11.006
Abstract: Immunoglobulin light chain amyloidosis (AL) is a plasma cell disorder characterized by overproduction and deposition of monoclonal immunoglobulin (Ig) light chains (LC) or variable region fragments as amyloid fibrils in various organs and tissues. Much… read more here.
Keywords: immunoglobulin; oxidative post; post translational; immunoglobulin light ... See more keywords
Unfolding and Aggregation Pathways of Variable Domains from Immunoglobulin Light Chains.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00704
Abstract: Light chain amyloidosis is the most common form of systemic amyloidosis. This disease is caused by the formation and deposition of amyloid fibers made from immunoglobulin light chains. Environmental conditions such as pH and temperature… read more here.
Keywords: unfolding aggregation; aggregation; aggregation pathways; light chains ... See more keywords
Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00339
Abstract: In immunoglobulin light-chain (LC) amyloidosis, transient unfolding or unfolding and proteolysis enable aggregation of LC proteins, causing potentially fatal organ damage. A drug that kinetically stabilizes LCs could suppress aggregation; however, LC sequences are variable… read more here.
Keywords: discovery potent; immunoglobulin; immunoglobulin light; potent coumarin ... See more keywords
Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021
Sign Up to like & getrecommendations! Published in 2021 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00483-7
Abstract: Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients presenting with these symptoms. More… read more here.
Keywords: immunoglobulin light; amyloidosis; chain amyloidosis; light chain ... See more keywords
Immunoglobulin light chain amyloid aggregation.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc04396e
Abstract: Light chain (AL) amyloidosis is a devastating, complex, and incurable protein misfolding disease. It is characterized by an abnormal proliferation of plasma cells (fully differentiated B cells) producing an excess of monoclonal immunoglobulin light chains… read more here.
Keywords: immunoglobulin light; light; amyloidosis; light chain ... See more keywords
Antibody‐based immunotherapy for treatment of immunoglobulin light‐chain amyloidosis
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16697
Abstract: Immunoglobulin light‐chain (AL) amyloidosis is a clonal plasma cell disorder characterised by production and deposition of misfolded monoclonal light chains in vital organs with potential to cause irreversible organ damage. The treatment of AL amyloidosis… read more here.
Keywords: chain amyloidosis; treatment; immunoglobulin light; amyloidosis ... See more keywords
Haematologic responses and survival do not significantly decrease with subsequent lines of therapy in systemic immunoglobulin light chain amyloidosis: results from an analysis of real‐world longitudinal data
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17636
Abstract: Systemic immunoglobulin light chain amyloidosis (AL) is an incurable disorder, and the natural history is incompletely understood. In this study, we describe its natural history based on an analysis of real‐world longitudinal data. All patients… read more here.
Keywords: chain amyloidosis; systemic immunoglobulin; analysis real; immunoglobulin light ... See more keywords
Rapid Complete Response to Single-Agent Bcl-2 Inhibitor Venetoclax in a Heart-Transplanted Patient with Triple Refractory Immunoglobulin Light-Chain Amyloidosis
Sign Up to like & getrecommendations! Published in 2020 at "Acta Haematologica"
DOI: 10.1159/000504355
Abstract: Immunoglobulin light-chain amyloidosis (AL) is a disease with limited treatment options due to the frailty of patients caused by organ damage. Since the clonal plasma cells often contain the cytogenetic aberration t(11;14), the Bcl-2 inhibitor… read more here.
Keywords: inhibitor venetoclax; chain amyloidosis; bcl inhibitor; immunoglobulin light ... See more keywords