T‐cell immunoglobulin mucin 3 blockade drives an antitumor immune response in head and neck cancer
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12029
Abstract: T‐cell immunoglobulin mucin 3 (TIM3) contributes to immune suppression during progression of many cancers, but the precise role of TIM3 in head and neck squamous cell carcinoma (HNSCC) is not clearly understood. In this study,… read more here.
Keywords: immunoglobulin mucin; tim3; expression; cell immunoglobulin ... See more keywords
Fragment-Based Discovery of Small Molecules Bound to T-Cell Immunoglobulin and Mucin Domain-Containing Molecule 3 (TIM-3).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01336
Abstract: T-cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3; HAVCR2) has emerged as an attractive immune checkpoint target for cancer immunotherapy. TIM-3 is a negative regulator of the systemic immune response to cancer and is expressed… read more here.
Keywords: domain containing; molecule; immunoglobulin mucin; tim ... See more keywords
T cell immunoglobulin and mucin domain protein 3 inhibits glycolysis in RAW 264.7 macrophages through Hexokinase 2
Sign Up to like & getrecommendations! Published in 2020 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12981
Abstract: T cell immunoglobulin and mucin domain‐3 (Tim‐3), an immune checkpoint molecule, plays critical roles in maintaining innate immune homeostasis; however, the mechanisms underlying these roles remain to be determined. Here, we determined that Tim‐3 controls… read more here.
Keywords: glycolysis; immunoglobulin mucin; cell immunoglobulin; tim ... See more keywords
The Emerging Role of T-Cell Immunoglobulin Mucin-3 in Breast Cancer: A Promising Target For Immunotherapy
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DOI: 10.3389/fonc.2021.723238
Abstract: Cancer treatment through immune checkpoint receptor blockade has made significant advances in the recent years. However, resistance to the current immune checkpoint inhibitors (ICIs) has been observed in many patients, who consequently do not respond… read more here.
Keywords: immunoglobulin mucin; target; breast cancer; cancer ... See more keywords
T-cell immunoglobulin mucin-3 as a potential inducer of the epithelial-mesenchymal transition in hepatocellular carcinoma
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DOI: 10.3892/ol.2017.6961
Abstract: T-cell immunoglobulin mucin (TIM)-3 is an important member of the TIM gene family, which was thought to contribute to the progression of numerous types of cancer, including hepatocellular carcinoma (HCC); however, the mechanism underlying TIM-3… read more here.
Keywords: hepatocellular carcinoma; hcc; immunoglobulin mucin; epithelial mesenchymal ... See more keywords