Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro.
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DOI: 10.1182/bloodadvances.2020002372
Abstract: Community-acquired pneumonia by primary or superinfections with Streptococcus pneumoniae can lead to acute respiratory distress requiring mechanical ventilation. The pore-forming toxin pneumolysin alters the alveolar-capillary barrier and causes extravasation of protein-rich fluid into the interstitial… read more here.
Keywords: pneumolysin induces; immunoglobulin preparations; platelet activation; pneumolysin ... See more keywords