Chromatin priming elements establish immunological memory in T cells without activating transcription
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600184
Abstract: We have identified a simple epigenetic mechanism underlying the establishment and maintenance of immunological memory in T cells. By studying the transcriptional regulation of inducible genes we found that a single cycle of activation of… read more here.
Keywords: transcription; immunological memory; memory cells; chromatin priming ... See more keywords
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.07.049
Abstract: Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we show that memory T cells collapsed in secondary lymphoid organs in the context… read more here.
Keywords: immunological memory; bone marrow; dietary restriction; memory ... See more keywords
NRP1 cripples immunological memory
Sign Up to like & getrecommendations! Published in 2020 at "Nature Immunology"
DOI: 10.1038/s41590-020-0759-5
Abstract: Durable responses to immunotherapy require the development of robust CD8+ T cell memory. A new study indicates that NRP1 differs from other checkpoint receptors as it functions as a checkpoint for the generation of memory. read more here.
Keywords: cripples immunological; immunological memory; nrp1 cripples; memory ... See more keywords
A potential platform of combining sialic acid derivative-modified paclitaxel cationic liposomes with antibody-drug conjugates inspires robust tumor-specific immunological memory in solid tumors.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01769e
Abstract: The recent approvals for antibody-drug conjugates (ADCs) in multiple malignancies in the past few years have fueled the ongoing development of this class of drug. However, the limitation of ADCs is selectivity toward cancer cells… read more here.
Keywords: tumor specific; immunological memory; specific immunological; memory ... See more keywords
IgE repertoire and immunological memory: compartmental regulation and antibody function
Sign Up to like & getrecommendations! Published in 2018 at "International Immunology"
DOI: 10.1093/intimm/dxy048
Abstract: Abstract It is now generally recognized that bone marrow is the survival niche for antigen-specific plasma cells with long-term immunological memory. These cells release antibodies into the circulation, needed to prime effector cells in the… read more here.
Keywords: immunological memory; response; ige; antigen ... See more keywords
T Cell Receptor and Cytokine Signaling Can Function at Different Stages to Establish and Maintain Transcriptional Memory and Enable T Helper Cell Differentiation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00204
Abstract: Experienced T cells exhibit immunological memory via a rapid recall response, responding to restimulation much faster than naïve T cells. The formation of immunological memory starts during an initial slow response, when naïve T cells… read more here.
Keywords: immunological memory; response; cytokine signaling; cell receptor ... See more keywords
Immunological Memory and Affinity Maturation After Vaccination in Patients With Propionic Acidemia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.774503
Abstract: Earlier studies have recommended routine childhood immunization in patients with propionic acidemia (PA); however, the literature presents insufficient data on the response to vaccines, notably specific IgG concentrations and avidity maturation, after measles, mumps, rubella… read more here.
Keywords: propionic acidemia; maturation; immunological memory; igg concentrations ... See more keywords
Trained Immunity Carried by Non-immune Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.03225
Abstract: “Trained immunity” is a term proposed by Netea to describe the ability of an organism to develop an exacerbated immunological response to protect against a second infection independent of the adaptative immunity. This immunological memory… read more here.
Keywords: immune cells; non immune; immunological memory; trained immunity ... See more keywords
Role of Immunological Memory Cells as a Therapeutic Target in Multiple Sclerosis
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DOI: 10.3390/brainsci7110148
Abstract: Pharmacological targeting of memory cells is an attractive treatment strategy in various autoimmune diseases, such as psoriasis and rheumatoid arthritis. Multiple sclerosis is the most common inflammatory disorder of the central nervous system, characterized by… read more here.
Keywords: immunological memory; memory cells; multiple sclerosis; role immunological ... See more keywords
Memory Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010038
Abstract: Immunological memory is a crucial part of the immune defense that allows organisms to respond against previously encountered pathogens or other harmful factors. Immunological memory is based on the establishment of epigenetic modifications of the… read more here.
Keywords: immunological memory; defense; memory; immune ... See more keywords