Measurement of Forces in the Immunological Synapse
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2877
Abstract: T cells screen the surfaces of antigen presenting cells (APC) for peptides originating from potentially harmful foreign matter in order to trigger an immunological response if necessary. The pivotal interaction in this process takes place… read more here.
Keywords: synapse; forces immunological; measurement forces; immunological synapse ... See more keywords
Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.02.02.478780
Abstract: Ligation of the T cell receptor (TCR) to peptide-MHC complexes initiates signaling leading to T cell activation. Regulation of T cell responses also requires mechanisms to stop this signaling and to downregulate surface expression of… read more here.
Keywords: cell; immunological synapse; clathrin; release ... See more keywords
A check on the immunological synapse.
Sign Up to like & getrecommendations! Published in 2023 at "Science signaling"
DOI: 10.1126/scisignal.adg6157
Abstract: Blocking Nogo receptor 1 on natural killer cells enhances cell killing by stabilizing contact with target cells. read more here.
Keywords: check immunological; immunological synapse;
αII-spectrin in T cells is involved in the regulation of cell-cell contact leading to immunological synapse formation?
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0189545
Abstract: T-lymphocyte activation after antigen presentation to the T-Cell Receptor (TCR) is a critical step in the development of proper immune responses to infection and inflammation. This dynamic process involves reorganization of the actin cytoskeleton and… read more here.
Keywords: involved regulation; immunological synapse; formation; spectrin ... See more keywords
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009771
Abstract: The Salmonella enterica effector SteD depletes mature MHC class II (mMHCII) molecules from the surface of infected antigen-presenting cells through ubiquitination of the cytoplasmic tail of the mMHCII β chain. This requires the Nedd4 family… read more here.
Keywords: cells cells; immunological synapse; dendritic cells; effector sted ... See more keywords
Orchestration of Immunological Synapse Assembly by Vesicular Trafficking
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00110
Abstract: Ligation of the T-cell antigen receptor (TCR) by cognate peptide bound to the Major Histocompatibility Complex on the surface of an antigen-presenting cell (APC) leads to the spatial reorganization of the TCR and accessory receptors… read more here.
Keywords: vesicular trafficking; orchestration immunological; immunological synapse; cell ... See more keywords
The Actin Cytoskeleton at the Immunological Synapse of Dendritic Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.679500
Abstract: Dendritic cells (DCs) are considered the most potent antigen-presenting cells. DCs control the activation of T cells (TCs) in the lymph nodes. This process involves forming a specialized superstructure at the DC-TC contact zone called… read more here.
Keywords: actin cytoskeleton; cytoskeleton immunological; immunological synapse; dendritic cells ... See more keywords
Corrigendum: WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.819050
Abstract: [This corrects the article DOI: 10.3389/fcell.2021.646077.]. read more here.
Keywords: corrigendum wasp; architecture immunological; unique architecture; crucial unique ... See more keywords
CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03115
Abstract: The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule… read more here.
Keywords: molecule; ccr7; immunological synapse; zap70 ... See more keywords
The Immunological Synapse: An Emerging Target for Immune Evasion by Bacterial Pathogens
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.943344
Abstract: Similar to other pathogens, bacteria have developed during their evolution a variety of mechanisms to overcome both innate and acquired immunity, accounting for their ability to cause disease or chronic infections. The mechanisms exploited for… read more here.
Keywords: immune evasion; evasion bacterial; immunological synapse; bacterial pathogens ... See more keywords
Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21093283
Abstract: In a signaling network, not only the functions of molecules are important but when (temporal) and where (spatial) those functions are exerted and orchestrated is what defines the signaling output. To temporally and spatially modulate… read more here.
Keywords: cell activation; cell; regulation; immunological synapse ... See more keywords