Immunological Tolerance
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1007/978-1-4939-8938-6
Abstract: Recently, adipose-derived stem cells (ASCs), obtained from fresh human lipoaspirate, have shown promise as immunomodulatory agents having demonstrated immunosuppressive functionality both in vitro and in vivo. A number of researchers have described the isolation of… read more here.
Keywords: ascs; immunological tolerance;
Strain-specific differences in reovirus infection of murine macrophages segregate with polymorphisms in viral outer-capsid protein σ3
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Virology"
DOI: 10.1128/jvi.01147-24
Abstract: ABSTRACT Mammalian orthoreovirus (reovirus) strains type 1 Lang (T1L) and type 3 Dearing-RV (T3D-RV) infect the intestine in mice but differ in the induction of inflammatory responses. T1L infection is associated with the blockade of… read more here.
Keywords: oral immunological; reovirus; outer capsid; immunological tolerance ... See more keywords
DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Tregs.
Sign Up to like & getrecommendations! Published in 2017 at "JCI insight"
DOI: 10.1172/jci.insight.94298
Abstract: Patients deficient in the guanine nucleotide exchange factor DOCK8 have decreased numbers and impaired in vitro function of Tregs and make autoantibodies, but they seldom develop autoimmunity. We show that, similarly, Dock8-/- mice have decreased… read more here.
Keywords: immune synapse; tregs; immunological tolerance; enforces immunological ... See more keywords