Sign Up to like & get
recommendations!
0
Published in 2020 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-020-0549-2
Abstract: Checkpoint-inhibitor (CPI) immunotherapy has achieved remarkable clinical success, yet its efficacy in ‘immunologically cold’ tumours has been modest. Interleukin-12 (IL-12) is a powerful cytokine that activates the innate and adaptive arms of the immune system;…
read more here.
Keywords:
collagen binding;
mouse tumours;
immunologically cold;
cold mouse ... See more keywords
Sign Up to like & get
recommendations!
1
Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004834
Abstract: Background Most pediatric cancers are considered immunologically cold with relatively few responding to immune checkpoint inhibition. We recently described an effective combination radio-immunotherapy treatment regimen (combination adaptive-innate immunotherapy regimen (CAIR)) targeting adaptive and innate immunity…
read more here.
Keywords:
immunologically cold;
mhc expression;
immunotherapy;
gd2 ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2022 at "Future oncology"
DOI: 10.2217/fon-2022-0392
Abstract: Immune checkpoint inhibitor therapy represents a significant advance in cancer care. The interaction between PD-1 and PD-L1 induces immune tolerance and the inhibition of this interaction is an effective treatment strategy for numerous malignancies. Despite…
read more here.
Keywords:
immunologically cold;
cold tumor;
plus tivozanib;
trial ... See more keywords
Sign Up to like & get
recommendations!
0
Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.763888
Abstract: Introduction Combining CpG oligodeoxynucleotides with anti-OX40 agonist antibody (CpG+OX40) is able to generate an effective in situ vaccine in some tumor models, including the A20 lymphoma model. Immunologically “cold” tumors, which are typically less responsive…
read more here.
Keywords:
tumor;
immunologically cold;
cpg ox40;
situ vaccine ... See more keywords