Toward a Better Regeneration through Implant‐Mediated Immunomodulation: Harnessing the Immune Responses
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Science"
DOI: 10.1002/advs.202100446
Abstract: Abstract Tissue repair/regeneration, after implantation or injury, involves comprehensive physiological processes wherein immune responses play a crucial role to enable tissue restoration, amidst the immune cells early‐stage response to tissue damages. These cells break down… read more here.
Keywords: immunomodulation; immune responses; regeneration; tissue ... See more keywords
Surface Modification of Bacteria to Optimize Immunomodulation for Advanced Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200574
Abstract: Bacteria have been widely exploited as therapeutic agents for immunotherapy due to their native immunogenicity, living characteristic, and genetic manipulability. However, conventional bacteria‐based immunotherapy often suffers from dose‐dependent safety issues and poor treatment efficacy. Harnessing… read more here.
Keywords: advanced immunotherapy; surface; modification bacteria; immunomodulation ... See more keywords
The Expression of Immunomodulation-Related Cytokines and Genes of Adipose- and Bone Marrow-Derived Human Mesenchymal Stromal Cells from Early to Late Passages
Sign Up to like & getrecommendations! Published in 2018 at "Tissue Engineering and Regenerative Medicine"
DOI: 10.1007/s13770-018-0147-5
Abstract: BACKGROUND:Mesenchymal stromal cells (MSCs) are multipotent stem cells that can differentiate into several cell types. In addition, many studies have shown that MSCs modulate the immune response. However, little information is currently available regarding the… read more here.
Keywords: mesenchymal stromal; immunomodulation; stromal cells; early late ... See more keywords
Transdermal immunomodulation: Principles, advances and perspectives☆
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Drug Delivery Reviews"
DOI: 10.1016/j.addr.2018.03.010
Abstract: &NA; Immunomodulation, manipulation of the immune responses towards an antigen, is a promising strategy to treat cancer, infectious diseases, allergies, and autoimmune diseases, among others. Unique features of the skin including the presence of tissue‐resident… read more here.
Keywords: immunomodulation principles; immunomodulation; delivery; transdermal immunomodulation ... See more keywords
T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31979-1
Abstract: Multipotential stromal cells (MSCs) demonstrate strong immunomodulation capabilities following culture expansion. We have previously demonstrated that human cancellous bone fragments (CBFs) clinically used as viable allografts for spinal fusion have resident MSCs that exhibit T… read more here.
Keywords: clinically used; human cancellous; immunomodulation; cancellous bone ... See more keywords
Biomaterials-based immunomodulation enhances survival of murine vascularized composite allografts.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm01845d
Abstract: Vascularized composite allotransplantation (VCA) is a restorative option for patients suffering from severe tissue defects not amenable to conventional reconstruction. However, the toxicities associated with life-long multidrug immunosuppression to enable allograft survival and induce immune… read more here.
Keywords: vascularized composite; survival; pro regenerative; allograft survival ... See more keywords
Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1550342
Abstract: ABSTRACT Radiofrequency ablation (RFA) of colorectal liver metastases activates a specific T-cell response that is ineffective in avoiding recurrence. Recently, local immunomodulation garnered interests as a way to improve the immune response. We were interested… read more here.
Keywords: radiofrequency ablation; immunomodulation; response; local immunomodulation ... See more keywords
Immunomodulation therapy using tolerogenic macrophages in a rodent model of pulmonary hypertension.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cells and development"
DOI: 10.1089/scd.2021.0007
Abstract: Inflammation plays a major role in the pathogenesis of pulmonary hypertension (PH). We sought to investigate the effects of a cell-based immunomodulation in a dysimmune model of PH. PH was induced in athymic nude rats… read more here.
Keywords: tolerogenic macrophages; pulmonary hypertension; immunomodulation; group ... See more keywords
Systematic Review of Host-Mediated Activity of Miltefosine in Leishmaniasis through Immunomodulation
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DOI: 10.1128/aac.02507-18
Abstract: Host immune responses are pivotal for the successful treatment of the leishmaniases, a spectrum of infections caused by Leishmania parasites. Previous studies speculated that augmenting cytokines associated with a type 1 T-helper cell (Th1) response… read more here.
Keywords: host mediated; treatment; immunomodulation; miltefosine ... See more keywords
Local Intracerebral Immunomodulation Using Interleukin-Expressing Mesenchymal Stem Cells in Glioblastoma
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-0803
Abstract: Purpose: Mesenchymal stem cells (MSCs) show an inherent brain tumor tropism that can be exploited for targeted delivery of therapeutic genes to invasive glioma. We assessed whether a motile MSC-based local immunomodulation is able to… read more here.
Keywords: glioblastoma; immunomodulation; mesenchymal stem; stem cells ... See more keywords
Viral infections and wheezing–asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Allergy"
DOI: 10.1186/s13601-020-00322-1
Abstract: Severe and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later life. In the first years of life, the… read more here.
Keywords: childhood; immunomodulation; viral infections; inception ... See more keywords