A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Cancer"
DOI: 10.1038/s41416-018-0006-0
Abstract: BackgroundPG545 (pixatimod) is a novel immunomodulatory agent, which has been demonstrated to stimulate innate immune responses against tumours in preclinical cancer models.MethodsThis Phase I study investigated the safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of… read more here.
Keywords: immunomodulatory agent; advanced solid; pixatimod; phase study ... See more keywords
An open-label, multi-center phase I study of the safety and tolerability of the novel immunomodulatory agent PG545 in subjects with advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.3083
Abstract: 3083Background: PG545 (pixatimod, pINN) is a novel immunomodulatory agent which stimulates dendritic cells (DC) via TLR9/IL-12 pathway to activate natural killer (NK) cells. It also inhibits tumour... read more here.
Keywords: open label; immunomodulatory agent; novel immunomodulatory; label multi ... See more keywords