The Functional Immune Response of Patients on Extracorporeal Life Support
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DOI: 10.1097/mat.0000000000000748
Abstract: Extracorporeal life support (ECLS) is a widely used lifesaving technology. Whether ECLS results in immune dysregulation is unclear. This study’s aim was to examine whether ECLS affected innate immune response. All patients placed on ECLS… read more here.
Keywords: immune response; response; extracorporeal life; life support ... See more keywords
Immunoparalysis in critically ill children
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DOI: 10.1111/imm.13595
Abstract: Immunoparalysis is associated with poorer outcomes in the paediatric intensive care unit (PICU) setting. We aimed to determine the group of patients with higher chances of immunoparalysis and correlate this status with increased risks of… read more here.
Keywords: frequency; immunoparalysis; classical monocytes; monocytes producing ... See more keywords
Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis
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DOI: 10.1186/s13054-020-03266-x
Abstract: Background Severe critical illness-induced immune suppression, termed immunoparalysis, is associated with longer duration of organ dysfunction in septic children. mRNA studies have suggested differential benefit of hydrocortisone in septic children based on their immune phenotype,… read more here.
Keywords: hydrocortisone; duration mods; longer duration; associated longer ... See more keywords
Utility of monocyte HLA-DR and rationale for therapeutic GM-CSF in sepsis immunoparalysis
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DOI: 10.3389/fimmu.2023.1130214
Abstract: Sepsis, a heterogeneous clinical syndrome, features a systemic inflammatory response to tissue injury or infection, followed by a state of reduced immune responsiveness. Measurable alterations occur in both the innate and adaptive immune systems. Immunoparalysis,… read more here.
Keywords: sepsis; hla; infection; immunoparalysis ... See more keywords