Long‐term clinical, imaging and cognitive outcomes association with MS immunopathology
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51723
Abstract: In this observational study on a cohort of biopsy‐proven central nervous system demyelinating disease consistent with MS, we examined the relationship between early‐active demyelinating lesion immunopattern (IP) with subsequent clinical course, radiographic progression, and cognitive… read more here.
Keywords: long term; immunopathology; cognitive outcomes; clinical imaging ... See more keywords
Host resources and parasite traits interact to determine the optimal combination of host parasite‐mitigation strategies
Sign Up to like & getrecommendations! Published in 2024 at "Ecology and Evolution"
DOI: 10.1002/ece3.11310
Abstract: Abstract Organisms have evolved diverse strategies to manage parasite infections. Broadly, hosts may avoid infection by altering behaviour, resist infection by targeting parasites or tolerate infection by repairing associated damage. The effectiveness of a strategy… read more here.
Keywords: immunopathology; host; parasite traits; parasite mitigation ... See more keywords
Immunopathology caused by impaired CD8+ T‐cell responses
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149528
Abstract: Recent findings indicate that many immunopathologies are at their roots a consequence of impaired immune responses (“too little” immunity) and not the result of primarily exaggerated immune responses (“too much” immunity). We have summarized this… read more here.
Keywords: cell; immunopathology; cd8 cell; caused impaired ... See more keywords
GVHD, IBD, and primary immunodeficiencies: The gut as a target of immunopathology resulting from impaired immunity
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149530
Abstract: The intestinal tract is the largest immunological organ in the body and has a central function of regulating local immune responses, as the intestinal epithelial barrier is a location where the immune system interacts with… read more here.
Keywords: ibd primary; immunopathology; primary immunodeficiencies; impaired immunity ... See more keywords
The Microbiome Modifies Manifestations of Hemophagocytic Lymphohistiocytosis in Perforin‐Deficient Mice
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202451061
Abstract: Primary hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory syndrome caused by inborn errors of cytotoxicity. Patients with biallelic PRF1 null mutations (encoding perforin) usually develop excessive immune cell activation, hypercytokinemia, and life‐threatening immunopathology in the… read more here.
Keywords: mice; pko; immunopathology; perforin deficient ... See more keywords
A novel role for coinhibitory receptors/checkpoint proteins in the immunopathology of sepsis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2mir0917-377r
Abstract: Coinhibitory molecules, such as PD‐1, CTLA‐4, 2B4, and BTLA, are an important new family of mediators in the pathophysiology of severe bacterial and/or fungal infection, as well as the combined insults of shock and sepsis.… read more here.
Keywords: sepsis; coinhibitory receptors; immunopathology; novel role ... See more keywords
Immunopathology of chronic critical illness in sepsis survivors: Role of abnormal myelopoiesis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4mr0922-690rr
Abstract: Sepsis remains the single most common cause of mortality and morbidity in hospitalized patients requiring intensive care. Although earlier detection and improved treatment bundles have reduced in‐hospital mortality, long‐term recovery remains dismal. Sepsis survivors who… read more here.
Keywords: sepsis; immunopathology; sepsis survivors; myelopoiesis ... See more keywords
COVID‐19 immunopathology: From acute diseases to chronic sequelae
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28122
Abstract: The clinical manifestation of coronavirus disease 2019 (COVID‐19) mainly targets the lung as a primary affected organ, which is also a critical site of immune cell activation by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).… read more here.
Keywords: immunopathology acute; immunopathology; covid immunopathology; acute diseases ... See more keywords
Comment on “Epigenetics in the pathogenesis of RA”
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-017-0638-9
Abstract: Dear Editors, Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects between 0.5 and 1% of individuals in the more economically developed countries [1]. The cause of the disease is yet to be determined,… read more here.
Keywords: dmrs; immunopathology; study; twin pairs ... See more keywords
Immunity and immunopathology in early human life
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-017-0657-6
Abstract: This special issue, BImmunocompetence of the Newborn^, is focused on the induction and regulation of immune responses in early life, because recent studies of early life immune ontogeny call into question the prevailing view of… read more here.
Keywords: immune system; life; immunopathology; early life ... See more keywords
Leishmaniasis immunopathology—impact on design and use of vaccines, diagnostics and drugs
Sign Up to like & getrecommendations! Published in 2020 at "Seminars in Immunopathology"
DOI: 10.1007/s00281-020-00788-y
Abstract: Leishmaniasis is a disease complex caused by 20 species of protozoan parasites belonging to the genus Leishmania . In humans, it has two main clinical forms, visceral leishmaniasis (VL) and cutaneous or tegumentary leishmaniasis (CL),… read more here.
Keywords: immunopathology impact; leishmaniasis; leishmaniasis immunopathology; vaccines diagnostics ... See more keywords