Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1.
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DOI: 10.1002/eji.202350449
Abstract: ER aminopeptidase 1 (ERAP1) is an ER-resident aminopeptidase that excises N-terminal residues of peptides that then bind onto Major Histocompatibility Complex I molecules (MHC-I) and indirectly modulates adaptive immune responses. ERAP1 contains an allosteric regulatory… read more here.
Keywords: distinct modulation; immunopeptidome; allosteric regulatory; regulatory site ... See more keywords