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   Articles with "immunoproteasome" as a keyword



A comparative analysis between proteasome and immunoproteasome inhibition in cellular and humoral alloimmunity

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recommendations! Published in 2017 at "International Immunopharmacology"

DOI: 10.1016/j.intimp.2017.06.009

Abstract: Abstract Triggered by the successful administration of the proteasome inhibitor bortezomib in kidney transplant recipients with acute or chronic antibody‐mediated rejection, we evaluated the effect of the proteasome inhibitor CEP‐18770 and of the selective immunoproteasome… read more here.

Keywords: alloimmunity; inhibitor; proteasome; immunoproteasome ... See more keywords
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Co-inhibition of immunoproteasome subunits LMP2 and LMP7 enables prevention of transplant arteriosclerosis.

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recommendations! Published in 2022 at "Cardiovascular research"

DOI: 10.1093/cvr/cvac181

Abstract: AIMS The loss of vascular wall cells in allotransplanted arteries is the initial event leading to transplant arteriosclerosis (TA) and ensuing loss of allograft function. Pharmacological agents able to prevent TA are currently lacking. We… read more here.

Keywords: immunoproteasome; inhibition; transplant arteriosclerosis; rejection ... See more keywords

AB0509 Kzr-616, a selective inhibitor of the immunoproteasome, shows a promising safety and target inhibition profile in a phase i, double-blind, single (SAD) and multiple ascending dose (MAD) study in healthy volunteers

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recommendations! Published in 2018 at "Annals of the Rheumatic Diseases"

DOI: 10.1136/annrheumdis-2018-eular.3344

Abstract: Background Proteasome inhibition is a standard of care for plasma cell malignancies. Bortezomib targets the constitutive proteasome and immunoproteasome, and is effective in the treatment of Systemic Lupus Erythematosus (SLE) and lupus nephritis (LN), but… read more here.

Keywords: kzr 616; none declared; immunoproteasome; inhibition ... See more keywords

Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II–Induced Atrial Fibrillation in Mice

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recommendations! Published in 2018 at "Hypertension"

DOI: 10.1161/hypertensionaha.117.10390

Abstract: Angiotensin II (Ang II) and inflammation are associated with pathogenesis of atrial fibrillation (AF), but the underlying molecular mechanisms of these events remain unknown. The immunoproteasome has emerged as a critical regulator of inflammatory responses.… read more here.

Keywords: atrial fibrillation; immunoproteasome; psmb10; mice ... See more keywords
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Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates

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recommendations! Published in 2022 at "Immune Network"

DOI: 10.4110/in.2022.22.e28

Abstract: The 26S proteasome irreversibly hydrolyzes polyubiquitylated substrates to maintain protein homeostasis; it also regulates immune responses by generating antigenic peptides. An alternative form of the 26S proteasome is the immunoproteasome, which contains substituted catalytic subunits… read more here.

Keywords: immunoproteasome; fluorogenic peptide; peptide substrates; activity ... See more keywords