On the role of the immunoproteasome in transplant rejection
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1084-0
Abstract: The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune diseases, colitis-associated… read more here.
Keywords: immunoproteasome transplant; transplantation; transplant rejection; immunoproteasome inhibition ... See more keywords
Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2018.10.022
Abstract: Chronic antibody-mediated rejection is the leading cause of allograft dysfunction and loss after kidney transplantation, and current immunosuppressive regimens fail to target the plasma cells that produce alloantibodies. We previously showed that treatment with the… read more here.
Keywords: plasma; unfolded protein; plasma cell; plasma cells ... See more keywords
Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02386
Abstract: Immunoproteasome (IP) inhibition holds potential as a novel treatment option for various immune-mediated pathologies. The IP inhibitor ONX 0914 reduced T cell cytokine secretion and Th17 polarization and showed pre-clinical efficacy in a range of… read more here.
Keywords: inhibition; proteostasis; cell activation; immunoproteasome inhibition ... See more keywords
Immunoproteasome Inhibition Ameliorates Aged Dystrophic Mouse Muscle Environment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314657
Abstract: Muscle wasting is a major pathological feature observed in Duchenne muscular dystrophy (DMD) and is the result of the concerted effects of inflammation, oxidative stress and cell senescence. The inducible form of proteasome, or immunoproteasome… read more here.
Keywords: inhibition; muscle; immunoproteasome inhibition; inhibition ameliorates ... See more keywords