The intragraft microenvironment as a central determinant of chronic rejection or local immunoregulation/tolerance
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DOI: 10.1097/mot.0000000000000373
Abstract: Purpose of review Chronic rejection is associated with persistent mononuclear cell recruitment, endothelial activation and proliferation, local tissue hypoxia and related biology that enhance effector immune responses. In contrast, the tumor microenvironment elicits signals/factors that… read more here.
Keywords: immunoregulation; tolerance; rejection; chronic rejection ... See more keywords
Psoriatic Serum Induce an Abnormal Inflammatory Phenotype and a Decreased Immunosuppressive Function of Mesenchymal Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc20210
Abstract: Background and Objectives Mesenchymal stem cells (MSCs) have immunomodulatory function and participate in the pathogenesis of many immunoregulation-related diseases, including psoriasis. Previously, we found that MSCs from psoriatic lesions overexpress the proinflammatory microRNA, miR-155 and… read more here.
Keywords: function; serum; immunoregulation; psoriatic serum ... See more keywords
SARM1: a key multifaceted component in immunoregulation, inflammation and neurodegeneration
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1521364
Abstract: The downstream signaling pathways of TLR activation involve a family of adaptor proteins, including MYD88, TIRAP, TRIF, TRAM, and SARM1. The first four proteins stimulate inflammatory and antiviral responses, playing crucial roles in innate immunity… read more here.
Keywords: sarm1 key; key multifaceted; multifaceted component; immunoregulation ... See more keywords
Mesenchymal Stem/Stromal Cells Derived from Dental Tissues Mediate the Immunoregulation of T Cells through the Purinergic Pathway
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25179578
Abstract: Human dental tissue mesenchymal stem cells (DT-MSCs) constitute an attractive alternative to bone marrow-derived mesenchymal stem cells (BM-MSCs) for potential clinical applications because of their accessibility and anti-inflammatory capacity. We previously demonstrated that DT-MSCs from… read more here.
Keywords: cd39; mesenchymal stem; purinergic pathway; stem ... See more keywords