Association of differential expression of immunoregulatory molecules and presence of targetable mutations may inform rational design of clinical trials
Sign Up to like & getrecommendations! Published in 2022 at "ESMO Open"
DOI: 10.1016/j.esmoop.2022.100396
Abstract: Background Immune checkpoint inhibitors (ICIs) and genomic biomarker-driven targeted therapies have revolutionized the modern oncologic treatment arsenal. The next step has been to combine targeted agents and ICIs. In doing so, some combination regimens may… read more here.
Keywords: differential expression; expression immunoregulatory; expression; presence ... See more keywords
Real-world data validation for differential expression of immunoregulatory molecules and targetable cancer genes may provide therapeutic insights into agnostic-driven trial designs.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.5_suppl.10
Abstract: 10Background: Targeting actionable genes and using immunotherapy have increased treatment options. We previously reported that some immunoregulatory molecules are found differentially regulated in ... read more here.
Keywords: data validation; real world; validation differential; differential expression ... See more keywords
Control of Immunoregulatory Molecules by miRNAs in T Cell Activation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02148
Abstract: MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation,… read more here.
Keywords: cell activation; cell; control immunoregulatory; immunoregulatory molecules ... See more keywords