Inhibition of mevalonate metabolism by statins augments the immunoregulatory phenotype of vascular endothelial cells and inhibits the costimulation of CD4+ T cells
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DOI: 10.1111/ajt.16872
Abstract: The statin family of therapeutics is widely used clinically as cholesterol lowering agents, and their effects to target intracellular mevalonate production is a key mechanism of action. In this study, we performed full transcriptomic RNA… read more here.
Keywords: mevalonate metabolism; costimulation; immunoregulatory phenotype; metabolism ... See more keywords