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   Articles with "immunosenescence" as a keyword



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Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology.

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recommendations! Published in 2021 at "Biogerontology"

DOI: 10.1007/s10522-021-09936-9

Abstract: An intricate relationship between impaired immune functions and the age-related accumulation of tissue senescent cells is rapidly emerging. The immune system is unique as it undergoes mutually inclusive and deleterious processes of immunosenescence and cellular… read more here.

Keywords: senescence; immunosenescence; biology; macrophage ... See more keywords

Voluntary exercise reverses immune aging induced by oxidative stress in aging mice

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recommendations! Published in 2019 at "Experimental Gerontology"

DOI: 10.1016/j.exger.2018.08.009

Abstract: &NA; Excessive oxidative stress leads to aging due to persistent damage to the cells, tissues, and the entire organism. Immunosenescence is also a devastating consequence of oxidative stress, but there is a lack of research… read more here.

Keywords: induced oxidative; voluntary exercise; immunosenescence; stress ... See more keywords

Immunosenescence evaluation of peripheral blood lymphocyte subsets in 957 healthy adults from 20 to 95 years old

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recommendations! Published in 2022 at "Experimental Gerontology"

DOI: 10.1016/j.exger.2021.111615

Abstract: Immunosenescence is characterized by an age-related decline in immune system function. Major efforts have been made to identify changes in peripheral blood lymphocyte subsets accompanying immunosenescence in elderly adults. However, the change trends of some… read more here.

Keywords: blood lymphocyte; age; 957 healthy; immunosenescence ... See more keywords

Altération des réponses vaccinales avec l’âge

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recommendations! Published in 2019 at "Revue des Maladies Respiratoires"

DOI: 10.1016/j.rmr.2019.07.008

Abstract: Resume Le vieillissement croissant de la population impose de prevenir les infections severes et frequentes sur ce terrain par des vaccins. Cependant, l’immunosenescence altere l’intensite et la qualite des reponses vaccinales, limitant ainsi l'efficacite des… read more here.

Keywords: apres ans; alt ration; reponses vaccinales; des reponses ... See more keywords

Tumor Microenvironment-Regulating Immunosenescence-Independent Nanostimulant Synergizing with Near-Infrared Light Irradiation for Antitumor Immunity.

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recommendations! Published in 2021 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.0c20063

Abstract: The combination of photothermal therapy (PTT) and toll-like receptor (TLR)-mediated immunotherapy can elicit antitumor immunity and modulate the immunosuppressive tumor microenvironment (TME). Unlike other TLRs, TLR-5 is a promising target for immune activation, as its… read more here.

Keywords: antitumor immunity; immunosenescence independent; immunosenescence; tlr ... See more keywords

Identifying an immunosenescence-associated gene signature in gastric cancer by integrating bulk and single-cell sequencing data

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-68054-x

Abstract: It has been believed that immunosenescence plays a crucial role in tumorigenesis and cancer therapy. Nevertheless, there is still a lack of understanding regarding its role in determining clinical outcomes and therapy selection for gastric… read more here.

Keywords: gene signature; cancer; immunosenescence; gastric cancer ... See more keywords

Immunoproteasome remodeling in senescing human macrophages reveals the loss of PA28αβ capping as a hallmark of immunosenescence

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recommendations! Published in 2025 at "Communications Biology"

DOI: 10.1038/s42003-025-08765-7

Abstract: Aging negatively impacts proteasome activity and/or content, and this impairment contributes to disrupted protein homeostasis and cellular dysfunction. However, little is known about proteasome complex dynamics during aging, particularly in the context of immunosenescence. Indeed,… read more here.

Keywords: immunosenescence; pa28; loss pa28; human macrophages ... See more keywords

Combined Training Improves Gene Expression Related to Immunosenescence in Obese Type 2 Diabetic Individuals

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recommendations! Published in 2024 at "Research Quarterly for Exercise and Sport"

DOI: 10.1080/02701367.2023.2299716

Abstract: ABSTRACT Purpose: The aim of this study was to investigate the effects of moderate combined training (CT) on both the gene expression of pro- and anti-inflammatory markers and senescence in the immune system in peripheral… read more here.

Keywords: immunosenescence; gene expression; combined training; expression ... See more keywords

Immunosenescence, inflammaging, and cancer immunotherapy efficacy

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recommendations! Published in 2022 at "Expert Review of Anticancer Therapy"

DOI: 10.1080/14737140.2022.2098718

Abstract: ABSTRACT Introduction Immunosenescence is a progressive remodeling of immune functions associated with a decreased ability of the immune system to set up an efficient immune response, both innate and adaptive, with an increase of highly… read more here.

Keywords: immunosenescence; immunotherapy; cancer immunotherapy; immunosenescence inflammaging ... See more keywords

An immunologist’s guide to immunosenescence and its treatment

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recommendations! Published in 2022 at "Expert Review of Clinical Immunology"

DOI: 10.1080/1744666x.2022.2106217

Abstract: ABSTRACT Introduction Aging causes several changes in the immune system, although immune aging is strongly influenced by individual immunological history, as well as genetic and environmental factors leading to inter-individual variability. Areas covered We focused… read more here.

Keywords: immunosenescence; immunologist guide; immunosenescence treatment; guide immunosenescence ... See more keywords

Immunosenescence Inventory—a multi-omics database for immune aging research

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae1102

Abstract: Abstract The immune system is intricately interconnected with all other bodily systems. As individuals age, the immune system undergoes changes known as immunosenescence, increasing susceptibility to disease, and contributing significantly to the morbidity and mortality… read more here.

Keywords: immune aging; immunosenescence; immunosenescence inventory; research ... See more keywords