Indoleamine 2,3-dioxygenase 1 inhibition reverses cancer-associated fibroblast-mediated immunosuppression in high-grade serous ovarian cancer.
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DOI: 10.1002/2211-5463.70126
Abstract: Cancer-associated fibroblasts (CAFs) contribute to immunosuppression in the ovarian cancer microenvironment, partly through upregulation of indoleamine 2,3-dioxygenase 1 (IDO1). This study examined CAF-mediated suppression of T-cell function and the potential of IDO1 inhibition to reverse… read more here.
Keywords: cancer; inhibition; ovarian cancer; immunosuppression ... See more keywords
Self‐Delivered Transformable Nanosystem Capable of Enhancing Photodynamic Effectiveness and Multi‐Target Ameliorating Immunosuppression for Treatment of Breast Cancer and Lung Metastasis
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DOI: 10.1002/adfm.202405051
Abstract: Homogeneous distribution and adequate accumulation of photosensitizer in tumor are essential for effective photodynamic therapy (PDT). However, the intricate tumor microenvironment (TME) often poses great challenges to the deep penetration and retention of therapeutic agents… read more here.
Keywords: delivered transformable; tumor; immunosuppression; metastasis ... See more keywords
Multi‐Hierarchical Fe Single Atom Nanozymes with Axially‐Coordinated O‐Fe‐N4 Active Centers Reshape Macrophage Epigenetics Against Immunosuppression
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DOI: 10.1002/adfm.202408141
Abstract: Immunosuppression is ubiquitous in solid tumors, characterized by few cytotoxic T infiltrations, abundant inflammation enrichment, immunosuppressive cell recruitment, etc., which is especially potentiated by incomplete tumor resection. In this report, multi‐hierarchical Fe single‐atom nanozymes (SAzymes)… read more here.
Keywords: atom nanozymes; hierarchical single; active centers; immunosuppression ... See more keywords
GeSe Nanosheets‐Mediated Local Sonocatalytic Immunosuppression of Rheumatoid Arthritis
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DOI: 10.1002/adfm.202420195
Abstract: The first‐line systemic administration of anti‐rheumatic immunosuppressants unavoidably causes adverse effects such as the increase in the risk of infection. While the emergence of local drug delivery for rheumatoid arthritis (RA) therapy can effectively reduce… read more here.
Keywords: local sonocatalytic; gese nanosheets; sonocatalytic immunosuppression; rheumatoid arthritis ... See more keywords
A Multiple Targeting Genome Editing System for Remodulation of Circulating Malignant Cells to Eliminate Cancer Immunosuppression and Restore Immune Responses
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DOI: 10.1002/adhm.202401223
Abstract: Cancer immunotherapy, which aims to eliminate cancer immunosuppression and reactivate anticancer immunity, holds great promise in oncology treatments. However, it is challenging to accurately study the efficacy of immunotherapy based on human‐derived cells through animal… read more here.
Keywords: cancer; cancer immunosuppression; circulating malignant; eliminate cancer ... See more keywords
Multichannel Immune Nanoregulators Suppress Lactic Acid Metabolism and Lactic Acid-Shaped Acidic Microenvironment to Uproot Anti-Tumor Immunosuppression.
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DOI: 10.1002/adma.202512230
Abstract: Lactic acid (LA) itself and the LA‐shaped acidic tumor microenvironment (TME) are identified as root causes of cancer immunosuppression, and no effective strategies address them. Here a multichannel immune nanoregulator is engineered to dampen acidic… read more here.
Keywords: lactic acid; tumor; immunosuppression; cancer immunosuppression ... See more keywords
Next‐generation pathology detection of T cell–antigen‐presenting cell immune synapses in human liver allografts
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DOI: 10.1002/hep.32666
Abstract: Background and Aims: In otherwise near‐normal appearing biopsies by routine light microscopy, next‐generation pathology (NGP) detected close pairings (immune pairs; iPAIRs) between lymphocytes and antigen‐presenting cells (APCs) that predicted immunosuppression weaning failure in pediatric liver… read more here.
Keywords: cell; immune synapses; pathology; formation ... See more keywords
Immunosuppression and cancer risk in kidney transplant recipients: A retrospective cohort study
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DOI: 10.1002/ijc.34875
Abstract: We assessed whether contemporary immunosuppression agents were associated with cancer among kidney transplant recipients (KTR), and if this association varied by age and sex. We studied a retrospective province‐wide cohort of primary KTR (1997–2016). Employing… read more here.
Keywords: cancer; risk; kidney transplant; immunosuppression ... See more keywords
CD73 in small extracellular vesicles derived from HNSCC defines tumour‐associated immunosuppression mediated by macrophages in the microenvironment
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DOI: 10.1002/jev2.12218
Abstract: Abstract Research on tumour cell‐derived small extracellular vesicles (sEVs) that regulate tumour microenvironment (TME) has provided strategies for targeted therapy of head and neck squamous cell carcinoma (HNSCC). Herein, we demonstrated that sEVs derived from… read more here.
Keywords: extracellular vesicles; derived hnscc; tumour associated; sevscd73 ... See more keywords
Frontline Science: OX40 agonistic antibody reverses immune suppression and improves survival in sepsis
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DOI: 10.1002/jlb.5hi0720-043r
Abstract: A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is… read more here.
Keywords: immunosuppression; cell function; sepsis; ox40 agonistic ... See more keywords
Longitudinal monitoring of Torque Teno virus DNAemia in kidney transplant recipients correlates with long‐term complications of inadequate immunosuppression
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DOI: 10.1002/jmv.29806
Abstract: Optimization of individual immunosuppression, which reduces the risks of both graft loss and patients' death, is considered the best approach to improve long‐term outcomes of renal transplantation. Torque Teno Virus (TTV) DNAemia has emerged as… read more here.
Keywords: long term; inadequate immunosuppression; immunosuppression; ttv dnaemia ... See more keywords