Next‐generation pathology detection of T cell–antigen‐presenting cell immune synapses in human liver allografts
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32666
Abstract: Background and Aims: In otherwise near‐normal appearing biopsies by routine light microscopy, next‐generation pathology (NGP) detected close pairings (immune pairs; iPAIRs) between lymphocytes and antigen‐presenting cells (APCs) that predicted immunosuppression weaning failure in pediatric liver… read more here.
Keywords: cell; immune synapses; pathology; formation ... See more keywords
CD73 in small extracellular vesicles derived from HNSCC defines tumour‐associated immunosuppression mediated by macrophages in the microenvironment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12218
Abstract: Abstract Research on tumour cell‐derived small extracellular vesicles (sEVs) that regulate tumour microenvironment (TME) has provided strategies for targeted therapy of head and neck squamous cell carcinoma (HNSCC). Herein, we demonstrated that sEVs derived from… read more here.
Keywords: extracellular vesicles; derived hnscc; tumour associated; sevscd73 ... See more keywords
Frontline Science: OX40 agonistic antibody reverses immune suppression and improves survival in sepsis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5hi0720-043r
Abstract: A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is… read more here.
Keywords: immunosuppression; cell function; sepsis; ox40 agonistic ... See more keywords
Immunosuppression in pediatric liver transplant recipients: Unique aspects
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DOI: 10.1002/lt.24677
Abstract: Pediatric liver transplantation has experienced improved outcomes over the last 50 years. This can be attributed in part to establishing optimal use of immunosuppressive agents to achieve a balance between minimizing the risks of allograft… read more here.
Keywords: recipients unique; liver transplant; immunosuppression; transplant recipients ... See more keywords
Combination of Photothermal Therapy with Anti-Inflammation Therapy Attenuates the Inflammation Tumor Microenvironment and Weakens Immunosuppression for Enhancement Antitumor Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202107071
Abstract: Photothermal therapy has gained widespread attention in cancer treatment, although its efficacy is suppressed due to the inflammatory response and immunosuppression, resulting in a discounted therapeutic effect. In this contribution, a high-performance NIR absorption organic… read more here.
Keywords: photothermal therapy; antitumor; combination; therapy ... See more keywords
Malignancy: An Adverse Effect of Immunosuppression.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_554
Abstract: Benefits of solid organ transplantation in end stage organ diseases are indisputable. Malignancy is a feared complication of solid organ transplantation and is a leading cause of mortality in patients with organ transplantation. Iatrogenic immunosuppression… read more here.
Keywords: solid organ; malignancy adverse; organ transplantation; malignancy ... See more keywords
Noradrenaline drives immunosuppression in sepsis: clinical consequences
Sign Up to like & getrecommendations! Published in 2020 at "Intensive Care Medicine"
DOI: 10.1007/s00134-020-06025-2
Abstract: The relationship between disease severity, immunosuppression, and outcome The immunological response in sepsis patients is complex, comprising concurrent proand anti-inflammatory responses. It has become increasingly clear that most sepsis patients do not succumb to an… read more here.
Keywords: sepsis; secondary infections; immunosuppression; disease severity ... See more keywords
High-grade glioma associated immunosuppression does not prevent immune responses induced by therapeutic vaccines in combination with Treg depletion
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-018-2214-0
Abstract: High-grade gliomas (HGG) exert systemic immunosuppression, which is of particular importance as immunotherapeutic strategies such as therapeutic vaccines are increasingly used to treat HGGs. In a first cohort of 61 HGG patients we evaluated a… read more here.
Keywords: treg depletion; high grade; immune responses; hgg patients ... See more keywords
Systemic and local immunosuppression in patients with high-grade meningiomas
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02342-8
Abstract: AimDespite current treatments, high-grade meningiomas continue to have a poor prognosis. Immunotherapy targeting immune checkpoints, such as PD-L1, has demonstrated significant success in controlling numerous malignancies. In this study, we investigate the extent of systemic… read more here.
Keywords: grade meningiomas; high grade; grade; systemic local ... See more keywords
The Evolution of Lung Transplant Immunosuppression
Sign Up to like & getrecommendations! Published in 2018 at "Drugs"
DOI: 10.1007/s40265-018-0930-6
Abstract: Advances in immunosuppression have been a key component to the ongoing success of lung transplantation. The demographics of patients receiving a lung transplant have evolved with older, more critically ill patients and those with previously… read more here.
Keywords: lung transplant; long term; lung transplantation; immunosuppression ... See more keywords
Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2020.11.016
Abstract: Combining chemo-therapeutics with immune checkpoint inhibitors facilitates killing cancer cells and activating the immune system through inhibiting immune escape. However, their treatment effects remain limited due to the compromised accumulation of both drugs and inhibitors… read more here.
Keywords: immunogenic cell; cell killing; cancer cells; immunosuppression ... See more keywords