Biosynthesis of Nonimmunosuppressive ProlylFK506 Analogues with Neurite Outgrowth and Synaptogenic Activity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c00767
Abstract: Separating the immunosuppressive activity of FK506 (1) from its neurotrophic activity is required to develop FK506 analogues as drugs for the treatment of neuronal diseases. Two new FK506 analogues, 9-deoxo-36,37-dihydro-prolylFK506 (2) and 9-deoxo-31-O-demethyl-36,37-dihydro-prolylFK506 (3) containing… read more here.
Keywords: biosynthesis nonimmunosuppressive; neurite outgrowth; prolylfk506; nonimmunosuppressive prolylfk506 ... See more keywords
Biosynthesis of Nonimmunosuppressive FK506 Analogues with Antifungal Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.9b00144
Abstract: A reduction in the strong immunosuppressive activity of FK506 (1) is essential for developing this compound as an antifungal agent. Seven new FK506 analogues modified at both the FK506-binding protein 12- and the calcineurin-binding regions… read more here.
Keywords: biosynthesis nonimmunosuppressive; fk506 analogues; antifungal activity; activity ... See more keywords
Macrocyclic Decanor- (C15) and Pentanor- (C20) Sesterterpenoids and C25 Precursor with Immunosuppressive Activity from Leucosceptrum canum.
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DOI: 10.1021/acs.orglett.4c04812
Abstract: Phytochemical investigation on the leaves of Leucosceptrum canum led to the discovery of leucosceptrone A (1), a rearranged pentanor-leucosceptrane sesterterpenoid (C20) with an unprecedented 6/9/5 tricyclic framework, and leucosceptrones B-E (2-5), three decanor-leucosesterterpane sesterterpenoids (C15)… read more here.
Keywords: immunosuppressive activity; macrocyclic decanor; c20; leucosceptrum canum ... See more keywords
Immunosuppressive activity of tumor-infiltrating myeloid cells in patients with meningioma
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1440931
Abstract: ABSTRACT Meningiomas WHO grade I and II are common intracranial tumors in adults that normally display a benign outcome, but are characterized by a great clinical heterogeneity and frequent recurrence of the disease. Although the… read more here.
Keywords: activity tumor; myeloid cells; tumor infiltrating; activity ... See more keywords
Netrin-1 promotes the immunosuppressive activity of MDSCs in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0658
Abstract: Myeloid-derived suppressive cells (MDSCs) inhibit antitumor immunity and confer a survival advantage for tumor evasion. Tumor cells also support MDSC expansion and recruitment by secreting multiple growth factors and cytokines, but the mechanisms by which… read more here.
Keywords: mdscs; netrin; activity mdscs; immunosuppressive activity ... See more keywords
Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041564
Abstract: Two unusual polyketide–sesquiterpene metabolites, craterodoratins T (1) and U (2), along with the known compound craterellin A (3), were isolated from the higher fungus Craterellus odoratus. The structures of isolated compounds were characterized based on… read more here.
Keywords: fungus craterellus; immunosuppressive activity; meroterpenoids immunosuppressive; craterellus odoratus ... See more keywords