Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300738
Abstract: Inflammation induced by autoreactive CD4+ T lymphocytes is a major factor in the pathogenesis of multiple sclerosis (MS). Immunosuppressive drugs, such as FTY720, are subsequently developed to prevent the migration of CD4+ T lymphocytes to… read more here.
Keywords: selectin; immunosuppressive drugs; lymph nodes; treatment ... See more keywords
Systemic lupus erythematosus patients contain B‐cell receptor repertoires sensitive to immunosuppressive drugs
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149596
Abstract: Immune repertoire (IR) during treatment may be a surrogate biomarker for disease response. Changes of the IR in systemic lupus erythematosus patients in response to immunosuppressive drugs were identified in ten SLE patients. Patients provided… read more here.
Keywords: sensitive group; erythematosus patients; immunosuppressive drugs; group ... See more keywords
Impact of Immunosuppressive Drugs on the Metabolism of T Cells.
Sign Up to like & getrecommendations! Published in 2018 at "International review of cell and molecular biology"
DOI: 10.1016/bs.ircmb.2018.05.009
Abstract: Energetic metabolism supports rapid cell growth and proliferation, differentiation, polarization, and effector functions of T cells. T lymphocytes have the remarkable plasticity that allows them to shape their metabolism to adapt to extracellular and intracellular… read more here.
Keywords: immunosuppressive drugs; drugs metabolism; impact immunosuppressive; metabolism ... See more keywords
Quantitative Analysis of Immunosuppressive Drugs Using Tungsten Disulfide Nanosheet-Assisted Laser Desorption Ionization Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "ACS nano"
DOI: 10.1021/acsnano.1c02016
Abstract: For organ transplantation patients, the therapeutic drug monitoring (TDM) of immunosuppressive drugs is essential to prevent the toxicity or rejection of the organ. Currently, TDM is done by immunoassays or liquid chromatography-tandem mass spectrometry (LC-MS/MS)… read more here.
Keywords: immunosuppressive drugs; mass spectrometry; analysis; mass ... See more keywords
The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review
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DOI: 10.1093/humupd/dmaa022
Abstract: Abstract BACKGROUND Information regarding the possible influence of immunosuppressive drugs on male sexual function and reproductive outcomes is scarce. Men diagnosed with immune-mediated diseases and a wish to become a father represent an important neglected… read more here.
Keywords: immunosuppressive drugs; pregnancy; sexual function; effect ... See more keywords
Safety and Efficacy of Switching Immunosuppressive Drugs for Maintenance Treatment in Patients with Systemic Lupus Erythematosus: A Retrospective Cohort Study.
Sign Up to like & getrecommendations! Published in 2022 at "Modern rheumatology"
DOI: 10.1093/mr/roac100
Abstract: OBJECTIVES To clarify the efficacy and safety of switching immunosuppressive drugs and to identify the predictive factors for treatment failure after switching in patients with systemic lupus erythematosus (SLE). METHODS We retrospectively evaluated patients with… read more here.
Keywords: safety; disease; switching immunosuppressive; efficacy ... See more keywords
Immunosuppressive drugs and associated complications in abdominal organ transplantation
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DOI: 10.1097/mcc.0000000000000927
Abstract: Purpose of review Intensive care management of patients who have undergone organ transplantation of liver, small bowel, pancreas, and/or kidney requires a basic knowledge of immunosuppression principles and the management of immunosuppressive medications. This review… read more here.
Keywords: organ transplantation; drugs associated; abdominal organ; immunosuppressive drugs ... See more keywords
Immunomodulatory and/or immunosuppressive drugs should not be stopped prior to skin tests for the assessment of drug allergy
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Dermatology"
DOI: 10.1111/bjd.20901
Abstract: The use of immunomodulatory and/or immunosuppressive therapy (IT) is increasingly common in the management of chronic inflammatory disease. Skin reactions to any drug (IT or not) are not rare in these patients, justifying allergological investigations.… read more here.
Keywords: immunosuppressive drugs; drug allergy; drug; immunomodulatory immunosuppressive ... See more keywords
LASSO‐derived nomogram predicting new‐onset diabetes mellitus in patients with kidney disease receiving immunosuppressive drugs
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DOI: 10.1111/jcpt.13713
Abstract: Patients with kidney disease receiving immunosuppressive drugs (ISDs) (tacrolimus, cyclosporine and glucocorticoids) have a high risk of developing new‐onset diabetes mellitus (NODM). We aimed to establish a precise and convenient model for predicting NODM in… read more here.
Keywords: disease receiving; receiving immunosuppressive; patients kidney; immunosuppressive drugs ... See more keywords
Human papillomavirus and immunosuppressive drugs in dermatology – a ‘neoplastic’ combination?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.14833
Abstract: Commentary to JEADV 2017-1413.R1 ‘Is there an increased risk of cervical neoplasia in atopic dermatitis patients treated with oral immunosuppressive drugs?’ Infection with certain genotypes of human papillomavirus (HPV) is causally linked to cervical neoplasia… read more here.
Keywords: immunosuppressive drugs; risk; dermatology; infection ... See more keywords
Gastroduodenal ulcers in liver transplant recipients under immunosuppressive therapy.
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DOI: 10.1159/000530472
Abstract: Introduction The proportion of gastroduodenal ulcers caused by drugs is increasing. However, the risk of gastroduodenal ulcer from drugs other than non-steroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin (LDA) is unclear. An association between immunosuppressive… read more here.
Keywords: ulcer group; liver transplant; gastroduodenal ulcers; immunosuppressive drugs ... See more keywords