Abstract 5652: IL-19 blockade reprograms glioblastoma immunosuppressive microenvironment and overcomes chemo-resistance as revealed by single-cell transcriptome analyses
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5652
Abstract: Glioblastoma multiforme (GBM) is the most aggressive brain tumor with chemo-resistant, immunosuppressive, and invasive property. Despite the application of standard therapies which include a combination of surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, tumor inevitably recurred… read more here.
Keywords: cell; cell transcriptome; immunosuppressive microenvironment; blockade ... See more keywords
Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
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DOI: 10.18632/oncotarget.14374
Abstract: Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by which cancer-associated fibroblasts (CAFs) affect the functional polarization of… read more here.
Keywords: microenvironment; associated fibroblasts; immunosuppressive microenvironment; cancer associated ... See more keywords
Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma
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DOI: 10.3389/fimmu.2022.1077768
Abstract: Introduction Multiple myeloma (MM) is still an incurable plasma cell malignancy. The efficacy of immunotherapy on MM remains unsatisfactory, and the underlying molecular mechanisms still are not fully understood. Methods In this study, we delineated… read more here.
Keywords: metabolic processes; multiple myeloma; immunosuppressive microenvironment; aberrant metabolic ... See more keywords
EIF4A3 serves as a prognostic and immunosuppressive microenvironment factor and inhibits cell apoptosis in bladder cancer
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DOI: 10.7717/peerj.15309
Abstract: EIF4A3 (Eukaryotic translation initiation factor 4A3 (EIF4A3) was recently recognized as an oncogene; however, its role in BLCA (bladder cancer) remains unclear. We explored EIF4A3 expression and its prognostic value in BLCA in public datasets,… read more here.
Keywords: immunosuppressive microenvironment; eif4a3; eif4a3 expression; expression ... See more keywords