Erlotinib-Gold(I) Complex Induces Leukemia Cell DC Differentiation and Remodels the Immunosuppressive Microenvironment.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01354
Abstract: Inducing differentiation of leukemia cells into dendritic cells (DC) is pivotal to reshaping the immunosuppressive microenvironment. Here, we report the synthesis of EG2, an erlotinib-gold(I) complex, which directly prompts the differentiation of acute myeloid leukemia… read more here.
Keywords: differentiation; immunosuppressive microenvironment; gold complex; erlotinib gold ... See more keywords
Light-Triggered Nanozymes Remodel the Tumor Hypoxic and Immunosuppressive Microenvironment for Ferroptosis-Enhanced Antitumor Immunity.
Sign Up to like & getrecommendations! Published in 2024 at "ACS nano"
DOI: 10.1021/acsnano.4c00844
Abstract: Cancer immunotherapy holds significant promise for addressing diverse malignancies. Nevertheless, its efficacy remains constrained by the intricate tumor immunosuppressive microenvironment. Herein, a light-triggered nanozyme Fe-TCPP-R848-PEG (Fe-MOF-RP) was designed for remodeling the immunosuppressive microenvironment. The Fe-TCPP-MOFs… read more here.
Keywords: light triggered; ferroptosis; tumor; immunosuppressive microenvironment ... See more keywords
Polyamine-Activated Carbonyl Stress Nanoplatform Synergistically Reverses Biofilm-Driven Immunosuppressive Microenvironment.
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DOI: 10.1021/acsnano.5c08038
Abstract: Polyamine metabolic dysregulation induced by implant-associated infections (IAIs) is a pivotal contributor to the formation of an immunosuppressive microenvironment. Excessive polyamines facilitate pathogen persistence by suppressing bacterial membrane lipid peroxidation (LPO) and enhancing DNA repair… read more here.
Keywords: stress nanoplatform; immunosuppressive microenvironment; polyamine; stress ... See more keywords
LEF1 is associated with immunosuppressive microenvironment of patients with lung adenocarcinoma
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DOI: 10.1097/md.0000000000039892
Abstract: Wnt/β-Catenin pathway plays an important role in the occurrence and progression of malignant tumors, especially PD-L1-mediated tumor immune evasion. However, the role of TCF/LEF, an important member of the Wnt/β-catenin pathway, in the tumor immunosuppressive… read more here.
Keywords: immunosuppressive microenvironment; tumor; luad patients; associated immunosuppressive ... See more keywords
Tumor-derived RAC1A159V mutation promotes an immunosuppressive microenvironment that represses response to immune checkpoint inhibitor
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.aea1212
Abstract: RAC1A159V is a hotspot mutation associated with poor prognosis in several cancers. By gene editing, we generated endogenous homozygous and heterozygous RAC1A159V mutations, which result in up-regulated RAC1 activity and mammalian target of rapamycin (mTOR)… read more here.
Keywords: immunosuppressive microenvironment; immune checkpoint; tumor; checkpoint inhibitor ... See more keywords
Correspondence on “METTL3 promotes an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5/CCL5 regulation” by Tong et al
Sign Up to like & getrecommendations! Published in 2025 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2025-012565
Abstract: an immunosuppressive microenvironment in bladder cancer via m6A-dependent CXCL5 read more here.
Keywords: cancer; immunosuppressive microenvironment; cancer via; via m6a ... See more keywords
Abstract 5652: IL-19 blockade reprograms glioblastoma immunosuppressive microenvironment and overcomes chemo-resistance as revealed by single-cell transcriptome analyses
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5652
Abstract: Glioblastoma multiforme (GBM) is the most aggressive brain tumor with chemo-resistant, immunosuppressive, and invasive property. Despite the application of standard therapies which include a combination of surgery, radiotherapy, and temozolomide (TMZ) chemotherapy, tumor inevitably recurred… read more here.
Keywords: cell; cell transcriptome; immunosuppressive microenvironment; blockade ... See more keywords
OSBPL3 modulates the immunosuppressive microenvironment and predicts therapeutic outcomes in pancreatic cancer
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DOI: 10.1186/s13062-025-00596-0
Abstract: Pancreatic cancer is characterized by a complex tumor microenvironment that hinders effective immunotherapy. Identifying key factors that regulate the immunosuppressive landscape is crucial for improving treatment strategies. We constructed a prognostic and risk assessment model… read more here.
Keywords: osbpl3; cancer; immunosuppressive microenvironment; cell ... See more keywords
Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
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DOI: 10.18632/oncotarget.14374
Abstract: Stromal cells in the tumor microenvironment (TME) closely interact with tumor cells and affect tumor cell behavior in diverse manners. We herein investigated the mechanisms by which cancer-associated fibroblasts (CAFs) affect the functional polarization of… read more here.
Keywords: microenvironment; associated fibroblasts; immunosuppressive microenvironment; cancer associated ... See more keywords
Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1077768
Abstract: Introduction Multiple myeloma (MM) is still an incurable plasma cell malignancy. The efficacy of immunotherapy on MM remains unsatisfactory, and the underlying molecular mechanisms still are not fully understood. Methods In this study, we delineated… read more here.
Keywords: metabolic processes; multiple myeloma; immunosuppressive microenvironment; aberrant metabolic ... See more keywords
Integrated analysis of single-cell and bulk transcriptome reveals hypoxia-induced immunosuppressive microenvironment to predict immunotherapy response in high-grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1450751
Abstract: Background Hypoxia is significantly associated with cancer progression and treatment outcomes. Nevertheless, the precise molecular mechanisms underlying the hypoxia-induced immunosuppressive microenvironment in high-grade serous ovarian cancer (HGSOC) are still not fully understood. Methods By analyzing… read more here.
Keywords: immunosuppressive microenvironment; analysis; microenvironment; hgsoc ... See more keywords