Abstract 4063: Target immunosuppressive myeloid cells to enhance cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4063
Abstract: A significant fraction of advanced prostate cancer (PCa) patients treated with androgen deprivation therapy (ADT) experience relapse with relentless progression to lethal metastatic castration-resistant prostate cancer (mCRPC). Immune checkpoint blockade (ICB) using antibodies against cytotoxic-T-lymphocyte-associated… read more here.
Keywords: mcrpc; immunotherapy; target immunosuppressive; cancer ... See more keywords
Reprogramming immunosuppressive myeloid cells facilitates immunotherapy for colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202012798
Abstract: Immune checkpoint blockade (ICB) has a limited effect on colorectal cancer, underlining the requirement of co‐targeting the complementary mechanisms. Here, we identified prostaglandin E2 (PGE2) receptor 4 (EP4) as the master regulator of immunosuppressive myeloid… read more here.
Keywords: myeloid cells; colorectal cancer; cancer; immunosuppressive myeloid ... See more keywords